Lecture 29: Neonatal Immunology and Immunosenescence Flashcards
(79 cards)
Neonates are immunologically naive, they can mount an immune response but lack exposure to antigen therefore all responses are ___ and ____
Primary and slow
What is immunosenscence
Occurs in aging animals and refers to the gradual deterioration of function and the immune system
What is the first immune organ to develop in fetus
Thymus
What is last immune organ to develop in fetus
Peyers patch
What is average gestation for calf
280 days
When can lymphocytes be found in calves
45 days
When can B cells be found in calves
59 days
Fetal cows can respond to viruses experimentally between 73-120 days already- what does this tell us
They can already distinguish between self and non-self
What is average gestation for foal
340 days
When do lymphocytes appear in thymus of foal
60-80 days
When can lymphocytes be found in blood of foal
120 days
When can plasma cells be found in foal
240 days
Report shows GVHD in immunodeficient host what kind of response does this demonstrate
Cell-mediated
When do horses begin IgE production
9-11 months
Average gestation for lamb
145 days
When do lymphocytes appear in blood of lambs
32 days
When can fetal lambs begin responding to viruses
50 days
How does the proportion of a/B and y/d T cells change in lamb over time
1 month prepartum- 18% of T cells are y/d
1 month postpartum 60% of T cells are y/d
What is average gestation for piglets
115 days
When does thymus develop in piglets
40 days
When can lymphocytes be found in piglets
38 days
When can B cells be found in piglets
50 days
Piglets have no __ cell activity until the piglet is several weeks old
NK
When can fetal pigs reject allografts
58 days
