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Flashcards in lecture 29 - Synaptic transmission Deck (40)
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31

_______ ________ arrives at the _________ terminal. The voltage-gated ___ channels open and there is a rapid influx of ___. _______ containing neurotransmitter move to the _________ membrane and fuse. The neurotransmitter ______ across the ______ ____ and binds to the ___________ receptors. Synaptic channels open. Postsynaptic _______ _________ is created.

_action_ _potential_ arrives at the _presynaptic_ terminal. The voltage-gated _Ca2+_ channels open and there is a rapid influx of _Ca2+_. _Vesicles_ containing neurotransmitter move to the _presynaptic_ membrane and fuse. The neurotransmitter _diffuses_ across the _synaptic_ _cleft_ and binds to the _postsynaptic_ receptors. Synaptic channels open. Postsynaptic _action_ _potential_ is created.

32

NMDA

a directly gated glutamate receptor

33

temporal summation

the higher the frequency of the synapse activation, from 1 synapse, the EPSPs can sum to reach threshold

34

end-plate potential due to ?

EPSP - therefore, increased permeability of (non-selective) ion channels to Na+ and K+ in the postsynaptic membrane

35

_______ synapse are used almost entirely in the brain

chemical

36

synaptic plasticity =

- process of weakening or strengthening synaptic transmission.
- Important in learning and memory.
- LTP (long-term potentiation) or LTD (long-term depression)

37

synaptic delay =

time between arrival of AP at presynaptic knob to AP regeneration in the postsynaptic knob. Aproximately = 0.5ms

38

3 key features of chemical synapses

1. specificity - specific neurotransmitters have specific effects
2. complexity - type, time, strength, etc.
3. plasticity - changes in synaptic structure and function

39

is end-plate potential supra- or sub- threshold

ALWAYS suprathreshold and ALWAYS triggers an AP

40

each neuron receives only 1 synapse TRUE/ FALSE

FALSE. they receive around 10,000