Flashcards in lecture 29 - Synaptic transmission Deck (40)
_______ ________ arrives at the _________ terminal. The voltage-gated ___ channels open and there is a rapid influx of ___. _______ containing neurotransmitter move to the _________ membrane and fuse. The neurotransmitter ______ across the ______ ____ and binds to the ___________ receptors. Synaptic channels open. Postsynaptic _______ _________ is created.
_action_ _potential_ arrives at the _presynaptic_ terminal. The voltage-gated _Ca2+_ channels open and there is a rapid influx of _Ca2+_. _Vesicles_ containing neurotransmitter move to the _presynaptic_ membrane and fuse. The neurotransmitter _diffuses_ across the _synaptic_ _cleft_ and binds to the _postsynaptic_ receptors. Synaptic channels open. Postsynaptic _action_ _potential_ is created.
a directly gated glutamate receptor
the higher the frequency of the synapse activation, from 1 synapse, the EPSPs can sum to reach threshold
end-plate potential due to ?
EPSP - therefore, increased permeability of (non-selective) ion channels to Na+ and K+ in the postsynaptic membrane
_______ synapse are used almost entirely in the brain
synaptic plasticity =
- process of weakening or strengthening synaptic transmission.
- Important in learning and memory.
- LTP (long-term potentiation) or LTD (long-term depression)
synaptic delay =
time between arrival of AP at presynaptic knob to AP regeneration in the postsynaptic knob. Aproximately = 0.5ms
3 key features of chemical synapses
1. specificity - specific neurotransmitters have specific effects
2. complexity - type, time, strength, etc.
3. plasticity - changes in synaptic structure and function
is end-plate potential supra- or sub- threshold
ALWAYS suprathreshold and ALWAYS triggers an AP