Lecture 6

Question 1

when symmetric division occurs what is made

Answer 1

a progenitor divides to make 2 new progenitors

Question 2

when asymettric divison occurs what is created

Answer 2

a progenitor and neuron are made

Question 3

in asymetric division what does numb bind to

Answer 3

notch

Question 4

t/f progenitors in all species have an apical and basal side

Answer 4

true

Question 5

does the pars complex sit on the apical or basal side

Answer 5

apical

Question 6

as a neuroblast prepares for assymetric mitrosis what does it express

Answer 6

inscuteable

Question 7

if we knock out numb what will occur

Answer 7

too many progenitors and not enough numb

Question 8

what is c elegans related to

Answer 8

the fate of nearly all cells is fixed at birth

Question 9

is the fate of a cell mostly based on intrinsic or environmental factors

Answer 9

intrinsic

Question 10

touch cells come from what type of cell

Answer 10

q cells

Question 11

what are 4 things that could be wrong if touch cells dont respond to touch

Answer 11

unc-86, mec-3, mec 12, mec 17

Question 12

what is unc 86 releated to

Answer 12

transcription factor that creates Q and Q1p

Question 13

without unc 86 what will be created

Answer 13

q divided into q and q

Question 14

what is mec 3 related to

Answer 14

it is an interneourn that causes newborn touch cells to differentiate into a touch cell instead of an interneourn

Question 15

what are the functions fo mec12 and mec 17

Answer 15

they are are proteins that allow touch cells to develo cytoskeletal features

Question 16

t/f a signal given to a cell early on can influence the fate of a daughter cellmuch later on

Answer 16

true

Question 17

what does ASEL detect

Answer 17

sodium

Question 18

what does ASER detect

Answer 18

choloride

Question 19

wht is asel a descendent of

Answer 19

ABa

Question 20

what is aser a descendent of

Answer 20

ABp

Question 21

ASEL makes what protein

Answer 21

die 1

Question 22

what protein does ASER make

Answer 22

cog1

Question 23

do all layers of neocortex look the same

Answer 23

no

Question 24

if you transport early born cells to the late cortex do they move

Answer 24

yes

Question 25

as development goes on , is fate more restricted

Answer 25

yes

Question 26

what is the marker associated with layer 5

Answer 26

fezf2

Question 27

where does layer 5 project

Answer 27

subcortically

Question 28

if fez5 is knocked out do subcortical projections occur

Answer 28

no

Question 29

where does the primary motor cortex project

Answer 29

subcortically

Question 30

wehre does the primary visual cortex project

Answer 30

superior colliculus

Question 31

the gene otx2 is assoiciated with which layer

Answer 31

layer 5

Question 32

where is otx2 primarily expressed

Answer 32

in the visual cortex

Question 33

in layer 5 neurons in v1 express what 2 things

Answer 33

fezf2 and otx2

Question 34

without otx2 will layer 5 neurons project correctly

Answer 34

no