Lecture #8 Flashcards
(26 cards)
what is is fascicilin 2 used for
it is necessary for fasiculation
if fascilciuln II is not there what will occur
defasiculation will occur
when a growth cone contacts high quantities of a repulsive substance what occurs
it will turn away or collapse
t/f different regions of the body express different kind of cams
true
what is the name of the transmembrane protein that repels dorsal root ganglia axons
sema3a
major inhibitory signls are coming from a family called what
semaphorins
what familiy is sema3A apart of
semaphorin
what are the receptors for semaphorins called
neuropilins and plexins
t/f different neurons express different cams which can draw the appropriate other axons towards them
true
the ventral spinal cord produces a transmembrane protein called
sema3
The drosphillia has a repulsion molecule called …and the receptor is called …
slit ….Robo
what kind of phenotype would you expect for a neuropilin knock out
this would be knocking out the do not enter sign . there would be overgrowth of projections
a guidepost is an example of what kind of distant cue
a long range cue
what is chemotaxis
the target release cues /chemicals that the growth cones can detect
what are 2 common diffusible cues that are used in chemotaxis That are secreted by guidepost cells
NGF and BDNF
what do netrins do
they attact axons over a distance of 100 microns
what is the name of the receptor for netrin
DCC
Where is netrin expressed
in the floor plate
what is attracted to netrin
axons
what is the name of the cell that pioneer axons to get to their target
guidepost cells
the process of moving along a chemical gradient is called
chemotaxis
after an axon crosses the midline , are axons attracted to netrin
no
what to proteins are found at the midline
sonic hedge hog and netrin
what is the name of the chemorepellant produced at the midline
slit
