lecture 7 Flashcards

(19 cards)

1
Q

what’s a MAP-t?

what disease is it linked to?

A

a microtubule associated protein tau
facilitates the transportation of neurotubules
-associated with Alzheimer’s disease.
amount and type of tau is modified preventing proper binding of tau to microtubules and thus tau accumulates and causes Alzheimers.
=get neurofibrilary tangles!

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2
Q

microtubules are made up of…

A

microfilaments (actin, mysoin, intermed filament)

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3
Q

cytochalasins

A

interfere with actin polymerization

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4
Q

*Where are cytokeratin intermediate filaments found?

A

epithelial cells

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5
Q

*where are desmin intermediate filaments usually found?

A

smooth and striated muscle

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6
Q

*glial and fibrillary acidic protein intermediate filaments found where?

A

in astrocytic glial cells

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7
Q

*where are neurofilament protein intermediate filaments found

A

neurons

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8
Q

*where are nuclearlamin intermediate filaments usually found?

A

nucleus

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9
Q

*where are vimentin intermediate filaments found?

A

mesodermal tissues (remember: vitamins for your skin!)

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10
Q

epidermolysis bulosa

A

causes blistering of the skin due to mutations in cytokeratin 5 and 14 (intermed. fila)

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11
Q

rosenthal’s fibers

A

brain cancer

intermed. filament prob with glial fibrils

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12
Q

how are centrosomes situated in relation to one another and where do they lie in terms of the cell?

A

they are perpendicular to eachother and lie around the nucleus

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13
Q

centrioles

arrangement

A

organize the mitosis

9x3 arrangement

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14
Q

well differentiated tumors vs. non- differentiated tumors

A

well differentiated more benign

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15
Q

cajaal bodies

A

involved in splicing pre mRNA to mature mRA

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16
Q

PML -pro myelocytic leukemia body

A

DNA repair

apoptosis initiation

17
Q

what’s the area between the inner nuclear membrane and the outer nuclear membrane called?
what is the nuclear membrane anchored to?

A

perinuclear space

nuclear lamina

18
Q

what’s the nuclear membrane continuous with

19
Q

what allows things into and out of the cell? what way requires GTP?

A

nuclear import

both