lecture 7 Flashcards
(19 cards)
what’s a MAP-t?
what disease is it linked to?
a microtubule associated protein tau
facilitates the transportation of neurotubules
-associated with Alzheimer’s disease.
amount and type of tau is modified preventing proper binding of tau to microtubules and thus tau accumulates and causes Alzheimers.
=get neurofibrilary tangles!
microtubules are made up of…
microfilaments (actin, mysoin, intermed filament)
cytochalasins
interfere with actin polymerization
*Where are cytokeratin intermediate filaments found?
epithelial cells
*where are desmin intermediate filaments usually found?
smooth and striated muscle
*glial and fibrillary acidic protein intermediate filaments found where?
in astrocytic glial cells
*where are neurofilament protein intermediate filaments found
neurons
*where are nuclearlamin intermediate filaments usually found?
nucleus
*where are vimentin intermediate filaments found?
mesodermal tissues (remember: vitamins for your skin!)
epidermolysis bulosa
causes blistering of the skin due to mutations in cytokeratin 5 and 14 (intermed. fila)
rosenthal’s fibers
brain cancer
intermed. filament prob with glial fibrils
how are centrosomes situated in relation to one another and where do they lie in terms of the cell?
they are perpendicular to eachother and lie around the nucleus
centrioles
arrangement
organize the mitosis
9x3 arrangement
well differentiated tumors vs. non- differentiated tumors
well differentiated more benign
cajaal bodies
involved in splicing pre mRNA to mature mRA
PML -pro myelocytic leukemia body
DNA repair
apoptosis initiation
what’s the area between the inner nuclear membrane and the outer nuclear membrane called?
what is the nuclear membrane anchored to?
perinuclear space
nuclear lamina
what’s the nuclear membrane continuous with
the rER
what allows things into and out of the cell? what way requires GTP?
nuclear import
both
