Flashcards in lecture 7 Deck (19):
what's a MAP-t?
what disease is it linked to?
a microtubule associated protein tau
facilitates the transportation of neurotubules
-associated with Alzheimer's disease.
amount and type of tau is modified preventing proper binding of tau to microtubules and thus tau accumulates and causes Alzheimers.
=get neurofibrilary tangles!
microtubules are made up of...
microfilaments (actin, mysoin, intermed filament)
interfere with actin polymerization
*Where are cytokeratin intermediate filaments found?
*where are desmin intermediate filaments usually found?
smooth and striated muscle
*glial and fibrillary acidic protein intermediate filaments found where?
in astrocytic glial cells
*where are neurofilament protein intermediate filaments found
*where are nuclearlamin intermediate filaments usually found?
*where are vimentin intermediate filaments found?
mesodermal tissues (remember: vitamins for your skin!)
causes blistering of the skin due to mutations in cytokeratin 5 and 14 (intermed. fila)
intermed. filament prob with glial fibrils
how are centrosomes situated in relation to one another and where do they lie in terms of the cell?
they are perpendicular to eachother and lie around the nucleus
organize the mitosis
well differentiated tumors vs. non- differentiated tumors
well differentiated more benign
involved in splicing pre mRNA to mature mRA
PML -pro myelocytic leukemia body
what's the area between the inner nuclear membrane and the outer nuclear membrane called?
what is the nuclear membrane anchored to?
what's the nuclear membrane continuous with