Flashcards in lecture 9 Deck (22):
1
where does the Extracellular matrix lie?
area between cells
2
what does the ECM do
it provides structural support
lubricant
barrier
diffusion of metabolites and growth factors (nutrition)
cell growth and differentiation
migration
3
what is the ECM broken up into
1) ground substance
2) Fibers
4
what are glycosaminoglycans?
disaccharides they have carboxyl groups that are hydrophillic and bond with water to keep the ECM hydrated
5
what is granulation tissue a hallmark of?
cellular damage and filling of ecm that eventually scars
-no replacement of functional tissue, just replace with ecm
6
what regulates cell division and how
ECM, the more ECM contact with CELLS the more likely it will divide
7
how is the ECM involved in repairing cells in a tissue that have been damaged?
it fills in and functions as a guide for the proliferation of new cells
8
name two glycosaminoglycans
chondroitin sulfate
hyaluronic acid
9
proteoglycan
an assemblage of glycosaminoglycans (the pro version ;))assembled around a protein core
10
syndecan
a transmembrane proteoglycan
co recptor for fibroblast growth factor
11
aggrecan
aggregation of proteoglycans (made up of glycosaminoglycans that complex with hyaluronic acid)
12
perlecan
(makes a pearl! ;))associated with growth and differentiation. development
mostly in basement and connective tissues
13
what are the three binding domins of the ECM
collagen
proteoglycans
cell adhesion molecule
14
what amino acid is measured to find the presence of collagen?
hydroxylysine and hydroxyproline
15
is collagen basic or acidic
acidophillic
16
2 ways collagen degraded
proteolytic
phagocytic
17
keloid fibers
excessive proliferation of collagen
18
reticular fibers
collagen 3
Branch
argyrophillic
basophillic via PAS positive
synthesized by fibrocytes, reticulocytes, smoothe myocytes and schwann cells
19
elastic fibers
comixed with collagen
branch
gives tissues elasticity
often in blood vessels forming lamellae
made up of: proelastin (DESMOSINE AND ISODESMOSINE), microfibril associated glycoprotein, fibrillin
20
Where does the basal lamina lie in terms of the cell
outside the cell
21
basal lamina vs basement membrane
basal lamina = lamina densa and lamina lucina
basement membrane is lamina dense and lamina lucida PLUS laminafibroreticularus
22