lecture 9 Flashcards Preview

Cell Bio > lecture 9 > Flashcards

Flashcards in lecture 9 Deck (22):
1

where does the Extracellular matrix lie?

area between cells

2

what does the ECM do

it provides structural support
lubricant
barrier
diffusion of metabolites and growth factors (nutrition)
cell growth and differentiation
migration

3

what is the ECM broken up into

1) ground substance
2) Fibers

4

what are glycosaminoglycans?

disaccharides they have carboxyl groups that are hydrophillic and bond with water to keep the ECM hydrated

5

what is granulation tissue a hallmark of?

cellular damage and filling of ecm that eventually scars
-no replacement of functional tissue, just replace with ecm

6

what regulates cell division and how

ECM, the more ECM contact with CELLS the more likely it will divide

7

how is the ECM involved in repairing cells in a tissue that have been damaged?

it fills in and functions as a guide for the proliferation of new cells

8

name two glycosaminoglycans

chondroitin sulfate
hyaluronic acid

9

proteoglycan

an assemblage of glycosaminoglycans (the pro version ;))assembled around a protein core

10

syndecan

a transmembrane proteoglycan
co recptor for fibroblast growth factor

11

aggrecan

aggregation of proteoglycans (made up of glycosaminoglycans that complex with hyaluronic acid)

12

perlecan

(makes a pearl! ;))associated with growth and differentiation. development
mostly in basement and connective tissues

13

what are the three binding domins of the ECM

collagen
proteoglycans
cell adhesion molecule

14

what amino acid is measured to find the presence of collagen?

hydroxylysine and hydroxyproline

15

is collagen basic or acidic

acidophillic

16

2 ways collagen degraded

proteolytic
phagocytic

17

keloid fibers

excessive proliferation of collagen

18

reticular fibers

collagen 3
Branch
argyrophillic
basophillic via PAS positive
synthesized by fibrocytes, reticulocytes, smoothe myocytes and schwann cells

19

elastic fibers

comixed with collagen
branch
gives tissues elasticity
often in blood vessels forming lamellae
made up of: proelastin (DESMOSINE AND ISODESMOSINE), microfibril associated glycoprotein, fibrillin

20

Where does the basal lamina lie in terms of the cell

outside the cell

21

basal lamina vs basement membrane

basal lamina = lamina densa and lamina lucina
basement membrane is lamina dense and lamina lucida PLUS laminafibroreticularus

22

what anchors the lamina densa to the lamina fibroreticularis

collagen 7