lecture 9 Flashcards
(22 cards)
where does the Extracellular matrix lie?
area between cells
what does the ECM do
it provides structural support lubricant barrier diffusion of metabolites and growth factors (nutrition) cell growth and differentiation migration
what is the ECM broken up into
1) ground substance
2) Fibers
what are glycosaminoglycans?
disaccharides they have carboxyl groups that are hydrophillic and bond with water to keep the ECM hydrated
what is granulation tissue a hallmark of?
cellular damage and filling of ecm that eventually scars
-no replacement of functional tissue, just replace with ecm
what regulates cell division and how
ECM, the more ECM contact with CELLS the more likely it will divide
how is the ECM involved in repairing cells in a tissue that have been damaged?
it fills in and functions as a guide for the proliferation of new cells
name two glycosaminoglycans
chondroitin sulfate
hyaluronic acid
proteoglycan
an assemblage of glycosaminoglycans (the pro version ;))assembled around a protein core
syndecan
a transmembrane proteoglycan
co recptor for fibroblast growth factor
aggrecan
aggregation of proteoglycans (made up of glycosaminoglycans that complex with hyaluronic acid)
perlecan
(makes a pearl! ;))associated with growth and differentiation. development
mostly in basement and connective tissues
what are the three binding domins of the ECM
collagen
proteoglycans
cell adhesion molecule
what amino acid is measured to find the presence of collagen?
hydroxylysine and hydroxyproline
is collagen basic or acidic
acidophillic
2 ways collagen degraded
proteolytic
phagocytic
keloid fibers
excessive proliferation of collagen
reticular fibers
collagen 3 Branch argyrophillic basophillic via PAS positive synthesized by fibrocytes, reticulocytes, smoothe myocytes and schwann cells
elastic fibers
comixed with collagen branch gives tissues elasticity often in blood vessels forming lamellae made up of: proelastin (DESMOSINE AND ISODESMOSINE), microfibril associated glycoprotein, fibrillin
Where does the basal lamina lie in terms of the cell
outside the cell
basal lamina vs basement membrane
basal lamina = lamina densa and lamina lucina
basement membrane is lamina dense and lamina lucida PLUS laminafibroreticularus
what anchors the lamina densa to the lamina fibroreticularis
collagen 7
