lecture 9 Flashcards

(22 cards)

1
Q

where does the Extracellular matrix lie?

A

area between cells

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2
Q

what does the ECM do

A
it provides structural support
lubricant
barrier
diffusion of metabolites and growth factors (nutrition) 
cell growth and differentiation
migration
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3
Q

what is the ECM broken up into

A

1) ground substance

2) Fibers

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4
Q

what are glycosaminoglycans?

A

disaccharides they have carboxyl groups that are hydrophillic and bond with water to keep the ECM hydrated

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5
Q

what is granulation tissue a hallmark of?

A

cellular damage and filling of ecm that eventually scars

-no replacement of functional tissue, just replace with ecm

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6
Q

what regulates cell division and how

A

ECM, the more ECM contact with CELLS the more likely it will divide

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7
Q

how is the ECM involved in repairing cells in a tissue that have been damaged?

A

it fills in and functions as a guide for the proliferation of new cells

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8
Q

name two glycosaminoglycans

A

chondroitin sulfate

hyaluronic acid

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9
Q

proteoglycan

A

an assemblage of glycosaminoglycans (the pro version ;))assembled around a protein core

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10
Q

syndecan

A

a transmembrane proteoglycan

co recptor for fibroblast growth factor

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11
Q

aggrecan

A

aggregation of proteoglycans (made up of glycosaminoglycans that complex with hyaluronic acid)

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12
Q

perlecan

A

(makes a pearl! ;))associated with growth and differentiation. development
mostly in basement and connective tissues

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13
Q

what are the three binding domins of the ECM

A

collagen
proteoglycans
cell adhesion molecule

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14
Q

what amino acid is measured to find the presence of collagen?

A

hydroxylysine and hydroxyproline

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15
Q

is collagen basic or acidic

A

acidophillic

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16
Q

2 ways collagen degraded

A

proteolytic

phagocytic

17
Q

keloid fibers

A

excessive proliferation of collagen

18
Q

reticular fibers

A
collagen 3
Branch
argyrophillic
basophillic via PAS positive
synthesized by fibrocytes, reticulocytes, smoothe myocytes and schwann cells
19
Q

elastic fibers

A
comixed with collagen
branch
gives tissues elasticity
often in blood vessels forming lamellae
made up of: proelastin (DESMOSINE AND ISODESMOSINE), microfibril associated glycoprotein, fibrillin
20
Q

Where does the basal lamina lie in terms of the cell

A

outside the cell

21
Q

basal lamina vs basement membrane

A

basal lamina = lamina densa and lamina lucina

basement membrane is lamina dense and lamina lucida PLUS laminafibroreticularus

22
Q

what anchors the lamina densa to the lamina fibroreticularis