lecture 9 Flashcards Preview

Cell Bio > lecture 9 > Flashcards

Flashcards in lecture 9 Deck (22)
Loading flashcards...
1
Q

where does the Extracellular matrix lie?

A

area between cells

2
Q

what does the ECM do

A
it provides structural support
lubricant
barrier
diffusion of metabolites and growth factors (nutrition) 
cell growth and differentiation
migration
3
Q

what is the ECM broken up into

A

1) ground substance

2) Fibers

4
Q

what are glycosaminoglycans?

A

disaccharides they have carboxyl groups that are hydrophillic and bond with water to keep the ECM hydrated

5
Q

what is granulation tissue a hallmark of?

A

cellular damage and filling of ecm that eventually scars

-no replacement of functional tissue, just replace with ecm

6
Q

what regulates cell division and how

A

ECM, the more ECM contact with CELLS the more likely it will divide

7
Q

how is the ECM involved in repairing cells in a tissue that have been damaged?

A

it fills in and functions as a guide for the proliferation of new cells

8
Q

name two glycosaminoglycans

A

chondroitin sulfate

hyaluronic acid

9
Q

proteoglycan

A

an assemblage of glycosaminoglycans (the pro version ;))assembled around a protein core

10
Q

syndecan

A

a transmembrane proteoglycan

co recptor for fibroblast growth factor

11
Q

aggrecan

A

aggregation of proteoglycans (made up of glycosaminoglycans that complex with hyaluronic acid)

12
Q

perlecan

A

(makes a pearl! ;))associated with growth and differentiation. development
mostly in basement and connective tissues

13
Q

what are the three binding domins of the ECM

A

collagen
proteoglycans
cell adhesion molecule

14
Q

what amino acid is measured to find the presence of collagen?

A

hydroxylysine and hydroxyproline

15
Q

is collagen basic or acidic

A

acidophillic

16
Q

2 ways collagen degraded

A

proteolytic

phagocytic

17
Q

keloid fibers

A

excessive proliferation of collagen

18
Q

reticular fibers

A
collagen 3
Branch
argyrophillic
basophillic via PAS positive
synthesized by fibrocytes, reticulocytes, smoothe myocytes and schwann cells
19
Q

elastic fibers

A
comixed with collagen
branch
gives tissues elasticity
often in blood vessels forming lamellae
made up of: proelastin (DESMOSINE AND ISODESMOSINE), microfibril associated glycoprotein, fibrillin
20
Q

Where does the basal lamina lie in terms of the cell

A

outside the cell

21
Q

basal lamina vs basement membrane

A

basal lamina = lamina densa and lamina lucina

basement membrane is lamina dense and lamina lucida PLUS laminafibroreticularus

22
Q

what anchors the lamina densa to the lamina fibroreticularis

A

collagen 7