Lecture 7- Helper T Cells and Their Response to Antigens Flashcards
What do dendritic cells use to present antigens to helper T cells
MHC II
What is the role of helper T cells
acts with the antigen to activate B cells, effector T cells, or make memory cells
Surface markers for helper T cells
CD4, CD3
What on a T helper cell must bind to MHC II antigen to activate
TCR, CD3, and CD4
Qualities of super antigens
Non-specific, exaggerated immune response
Cross-link to bypass co-stimulation of T helper cells
What generates Th1 cells
IL-12, IL-18, and IFN-gamma
What do Th1 cells respond to
intracellular viruses, parasites, tumors, and intracellular bacteria (cell mediated immunity)
What generates Th2 cells
IL-4
What do Th1 cells release
IL-2 and IFN-gamma
What do Th2 cells release
IL-4 and IL-13
What do Th2 cells respond to
allergies, helminths, antibody production, toxins, and extracellular bacteria (humoral immunity)
What generates Th17 cells
TGF-betta
IL-6
What do Th17 cells release
IL-17 and IL-22
What do Th17 cells respond to
All bacteria, fungi
What generates regulatory T cells
TGF-beta
