Lecture 8- B Cells and Their Response to Antigens Flashcards

1
Q

How many unique antibody’s?

A

Infinite

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2
Q

What type of immunity is transferred by bodily fluids?

A

Humoral immune response

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3
Q

Which cells are involved in humoral immunity?

A

Th2, B cells, Plasma cells

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4
Q

Which cells produce antibodies?

A

B cells and plasma cess

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5
Q

Which cells activate B cells

A

Th2

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6
Q

What is another name for humoral immunity?

A

Antibody mediated immunity

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7
Q

What markers are on the surface of B cells

A

CD21, CD19, CD40 and BCR

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8
Q

What is the BCR usually

A

IgM or IgD

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9
Q

What do the variable domains on the BCR form?

A

The antigen binding sites

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10
Q

What does the antigen-binding domain become once released from a B cell?

A

An antibody

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11
Q

How many antigen binding sites does one BCR have?

A

2

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12
Q

Are there more BCRs or TCRs per cell

A

BCRs

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13
Q

What are differentiated B cells

A

Plasma cells and memory cells

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14
Q

Are plasma cells long-lived

A

No

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15
Q

What are cancerous plasma cells known as?

A

Myelomas

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16
Q

What happens to an antigen once bound to a BCR?

A

It is ingested and displayed on MHC II

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17
Q

What neutralizes toxins?

A

Antibodies

18
Q

What kind of immunity is it when antibodies are transferred

A

Passive immunity

19
Q

What kind of immunity is acquired through exposure to disease causing agents?

A

Active immunity

20
Q

What type of immunity d vaccines provide?

A

Active Immunity

21
Q

What is the advantage of passive immunity

A

It is immediate

22
Q

Which type of immunity involves memory cells?

A

Active Immunity

23
Q

How do Th2 cells and B cells bind?

A

TCR binds to MHC II
CD4 binds to B cell
CD40L binds to CD40

24
Q

Can cytokines activate B cells alone?

25
What antibodies are produced by memory cells
IgG, IgD, IgA, and IgM
26
What are T-dependent antigens
Protein antigens (toxins) that require T cell binding before immune response
27
Are T-dependent responses slow of fast?
Slow
28
Are T-dependent antibodies high or low affinity
High
29
What do T-dependent antigens stimulate?
Long-lived plasma cells
30
What are T-independent antigens
Antigens that can activate B cells without T cell help
31
Are T-independent responses fast or slow?
Fast
32
Are T-independent antibodies low or high affinity?
low-affinity
33
What antibodies are produced in response to T-independent antigens
IgM
34
What is the role of PRRs on the surface of B and T cells
Chemotaxis
35
What is somatic mutation
The process that increases affinity maturation
36
Where does somatic mutation occur?
THe geminal centers
37
What happens to B cells that do not bind well to antigens during somatic mutation
Apoptosis
38
What type of antigens are T-independent
Polysaccharides
39
Which cells are found in geminal centers to help somatic mutation?
fDC
40
What does somatic mutation select for?
High affinity antibodies