Lecture14: Oxy-hemoglobin

Question 1

Explain co-operativity?

Answer 1

Where the binding Hb with one O2 molecule facilitates the uptake of the next one

Question 2

Which complication decreases Hb concentration?

Answer 2

Anemia

Question 3

Which complication reduces PaO2?

Answer 3

hypoxic hypoxia

Question 4

How much O2 can one gram of Hb combine with?

Answer 4

1.34 ml

Question 5

What is the total amount of Hb in the blood?

Answer 5

15 g/dL

Question 6

What is the Po2 value during P50?

Answer 6

26.5mmHg

Question 7

Name factors shifting the curve to the right?

Answer 7

Increased temp, PCo2, pH

Question 8

Factors shifting curve to the left?

Answer 8

Decreased Temp, Pco2, pH

Question 9

What does 2-3DPG do to the curve?

Answer 9

Shift it to the right

Question 10

What does 2-3DPG do to Hb affinity?

Answer 10

Decreases it

Question 11

What decreases 2-3DPG?

Answer 11

Storage of blood in blood banks, or acidosis

Question 12

What increases 2-3DPG?

Answer 12

High altitudes, chronic hypoxia, anemia and the lot. Exercise by lazy fucks

Question 13

Does fetal hemoglobin bind to 2-3DPG?

Answer 13

No

Question 14

Fetal Hb has 2 Y-polypeptide chains in place of ?

Answer 14

The singular Beta chain

Question 15

Where is Myoglobin’s greatest concentration?

Answer 15

Muscles specialized for sustained contraction

Question 16

How does acidosis decrease 2-3 DPG synthesis?

Answer 16

Via inhibition of RBC glycolysis