Lecture6: Compliance In Respiration Flashcards

1
Q

What is Transpulmonary pressure?

A

The pressure diff between the alveolar and pleural pressures

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2
Q

What the lungs are remarkably distensible, what does that mean?

A

Compliance is high and elastance is low

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3
Q

How much does the lung expand every 1 cm h2o

A

130ml

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4
Q

Why does the lung have a higher compliance than the total compliance?

A

Because chest wall movements are limited by the boney wall and respiratory muscles

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5
Q

What is the compliance of the lung alone?

A

200 ml/cm h2o

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6
Q

What are the 2 causes of Reduced Compliance?

A

Rigid lung and rigid thoracic cage

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7
Q

What are causes of Rigid thoracic cage?

A

Deformities of the vertebral column

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8
Q

Name 2 causes of Increased Compliance?

A

Old age and COPD

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9
Q

A male, whose a heavy smoker presents with abnormal dilation of air spaces between the terminal bronchioles, what does he have?

A

Emphysema

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10
Q

What is the cause of chronic bronchitis?

A

Chronic irritation by heavy cigarette smoke

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11
Q

What does the chronic irritation in chronic bronchitis lead to?

A

Hyper secretion of mucous

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12
Q

What is a Surfactant?

A

A surface tension lowering agent

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13
Q

What produces surfactant?

A

Type 2 alveolar bodies

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14
Q

What Is surfactant produced as?

A

Lamellar bodies

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15
Q

What does surfactant contain?

A

DPPC

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16
Q

What is excess surfactant removed by?

A

Pulmonary alveolar macrophages

17
Q

Functions of surfactant?

A

Decrease surface tension and stability of pulmonary alveoli

18
Q

Relevance of surfactant to lung compliance?

A

Increases it

19
Q

Does surfactant prevent collapse of lung?

A

Yes

20
Q

Why do infants get IRDS if born early?

A

They lack surfactant

21
Q

Factors that stimulate surfactant production?

A

Thyroids and glucocorticoids

22
Q

Factors that decrease formation of surfactant?

A

Insulin, long term O2