LG3.3 Immunology of Joint Pain – Dr. Moticka Flashcards Preview

NMSK A Test 2 > LG3.3 Immunology of Joint Pain – Dr. Moticka > Flashcards

Flashcards in LG3.3 Immunology of Joint Pain – Dr. Moticka Deck (26):
1

What is characteristics of rheumatoid arthritis?

-A chronic progressive disease causing inflammation in the joints and resulting in painful deformity and immobility, especially in the fingers, wrists, feet, and ankles.

2

What are the characteristic antibodies in rheumatoid arthritis?

RF and ACPA (Anti-citrullinated protein antibody)

3

In Rheumatoid arthritis what immune cells are auto reactive?

-Auto-reactive T-cells

4

Defining characteristics of Juvenile arthritis

-Chronic arthritis occurring before 16 years of age, unknown cause.

5

Environmental factors of Juvenile arthritis

Molecular mimicry with viral antigens

6

Genetics of Juvenile arthritis

Both HLA and non-HLA associations exist

7

Gender relations for Juvenile arthritis

-Systemic arthritis-no gender preference

8

Pathogenesis of Juvenile arthritis

Th1 mediated inflammation

9

Gender relations for RA

Female more dominate

10

Environmental factors of RA

Smoking and bronchial stress

11

Infectious agents of RA

Through molecular mimicry Epstein Barr, Cytomegalovirus, proteus species, E.Coli

12

Genetics of RA

HLA-DR4 and DRB1
PTPN22-Protein tyrosine phosphate Lyp
PAD14- Peptidyle arginine deiminase type IV

13

What is the innate mechanism of RA?

Damage, followed by increase of cytokines/chemokines, neutrophils, monocytes, mast cells, and finally chronic inflammation.

14

What cell stimulates damage?

Synovial fibroblasts stimulate damage

15

What is Spondyloarthritis?

Heterogeneous group of inflammatory diseases
-Spinal and peripheral oint arthritis
-Inflammation of attachments of tendons and ligaments to bones

16

What are the antigens involved in RA?

1) IgG filagren
2) Vimentin
3) Collagen
4) Fibronectin
5) G-6 phosphate isomerase
6) Proteoglycan
(NO single antigen found in all cases)

17

What is Citrullination?

Post translational modification of arginine

18

What molecule preferentially binds to citrullinated peptides?

HLA-DR4

19

What parallels frequency of Ankylosing spondylitis?

HLA-B27

20

What are immunologic targets of RA?

Cytokines, cells, and target immune components

21

What area FDA approved therapies?

1) TNF-alpha
2) IL-6
3) IL-1

22

What is the functions of IL-1 in RA?

1) Activates macrophages
2) Induces fibroblast proliferation
3) Activates chondrocytes to breakdown cartilage
4) Activates osteoclasts
5) CD80/86

23

What is molecule causes the development of Th1 cells?

IL-12 and IFN-gamma

24

What do Th17 cells produce?

IL-17, IL-21, IL-22, and TNF- Alpha

25

What is the function of Th17 cells?

They suppress T-reg cells and enhance inflammation.

26

Function of Th1?

Induce inflammation