Flashcards in LG3.8 Pharmacology of Joint Infections – Dr. Wightkin Deck (21):
What does the stem name "cef" or "ceph"?
What is the MOA of cephalosporin?
inhibits cell wall synthesis by transpeptide changes in
What is the MOA of Daptomycin?
Binds to bacterial membrane and cause depolarization of membrane potential. Results in inhibition of protein, DNA, and RNA synthesis.
What range of bacteria does Daptomycin treat?
Only Gram positive bacteria.
-Gas, pneumococci, MSSA, MRSA, Enterococci/VRE
What in the body interfere with the action of Daptomycin?
Daptomycin binds to lung surfactant and thus is ineffective agains pneumonia.
What are the adverse reactions of daptomycin?
decreased renal function, myoparht, Statins.
What is the MOA of Linezolid?
Binds to 23s ribosomal RNA of the 50S subunit
What are the ADME of linezolid?
Hepatic metabolism, IV and oral deliversimular serum levels; iv to oral switch de-escalation. Reversible bone marrow suppression (2 weeks of treatment)
What is serotonin syndrome?
Signs and symptoms include mental changes (confusion, hyperactivity, memory problems), muscle twitching, excessive swearing, shivering or shaking, diarrhea, trouble with coordination and or fever. Caused by Linezolid
What is the MOA of clindamycin?
Inhibits protein synthesis by binding to 50s ribosomal subunits
What is the spectrum of clindamycin?
Gram positive and Anaerobes
What drug has best activity against MSSA?
What drug is used in treating meningitis, Lyme Dx, and gonorrhea?
What drug is used in treating pseudomonas aeruginosa?
What drug is used to treat anaerobic bacteroides fragilis?
What drug is used to treat MRSA activity?
What are side effects of ceftriaxone?
Billary sludge, biliary pseudolithiasis, and hyperbilirubinemia
What are possible issue that may arise with ceftriaxone IV administration?
Calcium precipitates and reported deaths in 5 neonates
What drug should linezolid not be given with that may cause serotonin syndrome?
What new medication has the same MOA as Linezolid>