LG3.8 Pharmacology of Joint Infections – Dr. Wightkin Flashcards Preview

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Flashcards in LG3.8 Pharmacology of Joint Infections – Dr. Wightkin Deck (21):
1

What does the stem name "cef" or "ceph"?

cephalosporin

2

What is the MOA of cephalosporin?

inhibits cell wall synthesis by transpeptide changes in

3

What is the MOA of Daptomycin?

Binds to bacterial membrane and cause depolarization of membrane potential. Results in inhibition of protein, DNA, and RNA synthesis.

4

What range of bacteria does Daptomycin treat?

Only Gram positive bacteria.
-Gas, pneumococci, MSSA, MRSA, Enterococci/VRE

5

What in the body interfere with the action of Daptomycin?

Daptomycin binds to lung surfactant and thus is ineffective agains pneumonia.

6

What are the adverse reactions of daptomycin?

decreased renal function, myoparht, Statins.

7

What is the MOA of Linezolid?

Binds to 23s ribosomal RNA of the 50S subunit

8

What are the ADME of linezolid?

Hepatic metabolism, IV and oral deliversimular serum levels; iv to oral switch de-escalation. Reversible bone marrow suppression (2 weeks of treatment)

9

What is serotonin syndrome?

Signs and symptoms include mental changes (confusion, hyperactivity, memory problems), muscle twitching, excessive swearing, shivering or shaking, diarrhea, trouble with coordination and or fever. Caused by Linezolid

10

What is the MOA of clindamycin?

Inhibits protein synthesis by binding to 50s ribosomal subunits

11

What is the spectrum of clindamycin?

Gram positive and Anaerobes

12

What drug has best activity against MSSA?

Cefazolin

13

What drug is used in treating meningitis, Lyme Dx, and gonorrhea?

Ceftriaxone

14

What drug is used in treating pseudomonas aeruginosa?

Ceftazidime, Cefepime

15

What drug is used to treat anaerobic bacteroides fragilis?

Cefoxitin

16

What drug is used to treat MRSA activity?

Ceftaroline

17

What are side effects of ceftriaxone?

Billary sludge, biliary pseudolithiasis, and hyperbilirubinemia

18

What are possible issue that may arise with ceftriaxone IV administration?

Calcium precipitates and reported deaths in 5 neonates

19

What drug should linezolid not be given with that may cause serotonin syndrome?

SSRI (antidepressents)

20

What new medication has the same MOA as Linezolid>

Tedizolid

21

What is the spectrum of linezolid?

-Gram positive
-Nonselective inhibitor of monoamine oxidase