LG4.3 Arthritis II – Winfield Flashcards Preview

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Flashcards in LG4.3 Arthritis II – Winfield Deck (29):
1

What are general characteristics of reactive arthritis?

-Acute, polyarticular

2

What are the symptoms of reactive arthritis?

-Rash on hands, feet, penis.
-Urethritis, Iritis

3

What is the classic triad of reactive arthritis?

Arthritis, conjunctivitis, urethritis

4

What are the general symptoms of ankylosing spondylitis?

-persistent low back pain in teenager or early 20's
-Spinal fusion with stooped posture and loss of spinal mobility

5

Define spondylitis?

A painful condition of the spine resulting from the degeneration of the intervertebral disks.

6

What are the main characteristics of ankylosing spondylitis?

-More males
-In lumbar spine, hips, pelvis, eye
-Seronegitive spondyloarthropathies

7

What are the main genetic predisposition of ankylosing spondylitis?

Class 1: HLA-B27

8

What are the general characteristics of Enteropathic arthritis?

-20% of IBD develop a peripheral arthritis
-course of arthritis often fluctuates with the activity of the underlying bowel involvement.
-10-20% spinal involvement

9

What are extra-articular manifestations of enteropathic arthritis?

Inflammatory eye disease and cutaneous lesions

10

What is the problem in psoriasis?

-The skin grows to quickly forming skin lesions.
-Nail discolorations and pitting
-can develop arthritis

11

What is the cause of psoriasis?

T-cell mediated disease with a genetic basis

12

Who gets psoriasis?

-Males=females
-Caucasians

13

What is the general characteristics of Psoriatic arthritis?

-Skin lesions and nail discoloration
-caused by psoriasis

14

What does it mean for a diseases to be Seronegitive spondyloarthropathies?

-No RF and ACPA values
-increased HLA-B27

15

What is Inflammatory bowel disease?

Diseases that cause chronic recurrent inflammation of the intestines

16

What are the causes of inflammatory bowel disease?

-Genetic family risk
-Caucasians have higher risk
-Jew have higher risk
-Ages 10-30 and 50-60

17

What are the symptoms of inflammatory bowel disease?

Abdominal cramps and pain, diarrhea, weight loss, and hematochezia

18

What are the clinical presentation of Rheumatoid Arthritis?

-Joint tenderness and swelling
-Morning joint stiffness for an hour or more
-Progressive joint destruction

19

What are extra-articular manifestations of Rheumatoid Arthritis?

-Scleritis, pericarditis, conduction defects, lung nodules, pulmonary fibrosis, gastritis, peptic ulcer disease 2nd to NSAIDS.

20

What is the cause of Rheumatoid Arthritis?

-Unknown
-Possible infectious agent
-Genetic factors

21

What are risk factors of Rheumatoid Arthritis?

-Female 3:1 male
-Smoking
-onset at any age, most common 40-50

22

What are lab test for Rheumatoid Arthritis?

-RF
-Anti-cyclic cirtullinated peptide(ACCP)
-Increased ESR
-Increased CRP

23

What are the non-pharmacologic treatments for Rheumatoid Arthritis?

-Heat
-Range of motion exercises

24

What are pharmacologic treatments for Rheumatoid Arthritis?

-NSAIDS
-Corticosteroids
-Disease Modifying Antirheumatic Drugs (DMARD)
-Oral Hydroxychloroquine, Sulfasalazine, and Methotrexate

25

What are the clinical presentation of erosive inflammatory osteoarthritis?

-Typical OA has enlargement of bones over the distal and proximal finger joints.
-Swelling of the soft tissue in the proximal and distal interphalangeal joints.

26

What are common labs for erosive inflammatory osteoarthritis?

-RF/ACCP are negative
-ESR and CRP increased

27

What are the treatments of erosive inflammatory osteoarthritis?

-ROM exercises
-PRN pain meds and no steroidal anti-inflammatory drugs for symptom relief

28

What are main lab values for septic arthritis?

-Lab: Synovial WBC >100,000 PMNs are 90% or above

29

What are main causes of septic arthritis?

-Mycrobacterium SPP
-Fungal infections
-Viral infections