Lipid/Lipoprotein Disorders Flashcards Preview

Cardio 2 > Lipid/Lipoprotein Disorders > Flashcards

Flashcards in Lipid/Lipoprotein Disorders Deck (21):
1

Dietary/Exogenous Pathway

Chylomicrons carry shit around, become chylomicron remnants and go to liver

2

Chylomicron 4 Apo Proteins

ApoB48, and chylomicrons also have ApoC II and III, and then chylomicron remnants get ApoE which targets them to liver

3

Chylomicron composition

A lot of TGs, some cholesterol

4

Endogenous Pathway

Liver sends out VLDL, which becomes IDL, which gets ApoE so its targeted back to liver (or becomes LDL)

5

Endogenous Pathway Apo Prot(s)

Has B100, but also has CII and III, and gets ApoE to target to liver

6

LDL Composition

Lotta cholesterol comparatively

7

Best Estimate of Artherosclerotic Risk

Non-HDL cholesterol

8

Change in Fats After Eating

Not huge increase in cholesterol - increase in chylomics, which are mainly TGs so that's what spikes after meal

9

Size of Particles w/in a Subclass Importance

Smaller particles in a subclass associated w/ increased risk of CV disease

10

Familial Hypercholesterolemia

AD mut of B or E or R, inhibiting LDL clearance and presenting at birth

11

3 Visual Signs of Familial Hypercholesterolemia

Corneal Arcus
Thickened tendons, especially achilles
Xanthoma - cholesterol deposition often around eyes

12

High Cholesterol Diet Effect

Raises LDL levels by downreg'ing B/E Rs on Liver

13

3.5 Causes of Increased LDL Production

Familial Combined Hyperlipidemia
Acquired - obesity, nephrotic syndrome
Drugs - thiazides, corticosteroids, progestogens

14

Hypertriglyceridemia

Lipoprotein Lipase deficiency, enzyme that removes chylomicrons more effectively than it does VLDL. So mild deficiency is just VLDL accumulation, but severe can cause hyperchylomicronemia

15

4 Signs of Hyperchylomicronemia (3 visual, 1 clinical condition)

Milky serum
Lipemic pattern in eye (retinal vessels)
Eruptive Xanthomas
Acute pancreatitis

16

Familial Combined Hyperlipidemia

Overproduction of B100 containing particles, so you get lotsa small VLDLs from the liver which become a lot of small LDL

17

Familial Hypertriglyceridemia

Increased production of VLDL-TG (normal numbers of VLDL particles), but not LDL because not ApoB increase in production

18

Direct Pathway of HDL Cholesterol Transport

Packaged into HDL3 which then turns into HDL2 to dump its shit into liver

19

Indirect Pathway of HDL

HDL3 gives cholesterol to VLDL/LDL and receives TG from them

20

Dislipidemic/Lipid Triad

High TGs and Low HDL are a common combination, and always present w/ increased small, dense LDL

21

Lp(a)

LDL + Apolipoprotein A which is kinda like a shitty plasminogen protein which doesn't work but causes a lot more disease or something