Liver & Pancreatic Secretions in Digestion Flashcards Preview

Gastrointestinal > Liver & Pancreatic Secretions in Digestion > Flashcards

Flashcards in Liver & Pancreatic Secretions in Digestion Deck (25):
1

What hormone regulates gall bladder contraction?

CCK

2

What is the result of absence of bile?

steathorrhea

3

What are the components of bile?

water, bile pigments (bilirubin), bile salts, fatty acid, cholesterol, lecithin (emulsifier), inorganic salts

4

What component of bile causes gall stones?

cholesterol

5

What are bile salts derived from?

cholesterol

6

What is the structure of bile salts?

steroid structures with a carboxylic acid group that is commonly an amide linked to glycine or taurine to increase solubility

7

What is the function of bile acids?

they are detergents

8

Why does fat digestion require emulsifying action?

so that the enzymes can gain access

9

What enzymes are needed in fat digestion?

lipase and colipase

10

What is the purpose of enterohepatic circulation?

To reabsorb bile salts in the ileum so they can be reused

11

What makes up pancreatic secretions?

bicarbonate from duct cells and enzymes from acinar cells

12

What stimulates release of contents from exocrine pancreatic cells?

acetylcholine, CCK or secretin

13

Where is CCK produced?

in the duodenum

14

What are the actions of CCK?

gall bladder contraction, digestive enzyme release from pancreas, release of insulin and contributes to the feeling of fullness

15

What are zymogens?

Inactive enzymes

16

What activates zymogens?

other enzymes

17

What is the action of trypsin inhibitor?

Exists in the pancreas to inhibit any trypsin that is accidentally activated to prevent digestion of the pancreas

18

What activates trypsin?

enteropeptidase from intestinal enterocytes

19

What enzymes does trypsin activate?

chymotrypsin, elastase, carboxypeptidase, colipase

20

What activates lipase?

colipase

21

What gives the substrate specificity of serine proteases?

the properties of the S1 sub site adjacent to serine

22

What are the two main causes of pancreatitis?

alcohol abuse and gall stones

23

What is the most energy expensive nutrient?

protein - requires lots of transporters

24

What is orlistat?

A lipase inhibitor

25

How does margarine lower cholesterol reabsorption?

the phytosteroids block the receptors for reuptake of cholesterol in the terminal ileum