Loop Diuretics

Question 1

Medications

Answer 1

“-ide”

• Bumetanide
• Furosemide
• Torsemide

Question 2

Action

Answer 2

• Blocks the chloride pump which blocks sodium and chloride reabsorption into circulation
• Large amount of Na and Cl rich urine is excreted
• Powerful diuretic

Question 3

Indications

Answer 3

• Acute HF
• Acute pulmonary edema
• Edema r/t CHF, renal, or liver disease
• HTN

Question 4

Contraindications

Answer 4

• Allergy
• Electrolyte depletion
• Anuria/Severe renal failure
• Hepatic coma
• Pregnancy/lactation

Question 5

Cautions

Answer 5

• SLE
• Hyperglycemia
• Gout
• Children under 18 y/o

Question 6

Adverse effects

Answer 6

• Hypokalemia/hypocalcemia
• Hyperglycemia
• Ototoxicity
• Hypotension and dizziness

Question 7

Drug-Drug interactions

Answer 7

• Aminoglycosides or cisplatin: increased risk of ototoxicity
• Anticoagulation: anticoagulant effects are increased
• Indomethacin, ibuprofen, salicylates, or NSAIDs: decreased therapeutics effects of diuretic