Lymphoproliferative Disorders

Question 1

Myelos shift…..

Answer 1

left

toward bone marrow

Question 2

Immature Neutrophils

Answer 2

myelos

bands

Question 3

Leukemia

Answer 3

cancer of bone marrow, WBC, blood

Question 4

Leukocytosis

Answer 4

increased WBC count

Question 5

Neutrophilia

Answer 5

increased neutrophil count

Question 6

Lymphocytosis

Answer 6

increased lymphocyte count

Question 7

Leukopenia

Answer 7

decreased leukocyte count

Question 8

Neutropenia

Answer 8

decreased neutrophil count

Question 9

Lymphocytopenia

Answer 9

decreased lymphocyte count

Question 10

Pancytopenia

Answer 10

all blood parts decreased- WBC, RBC, PLT

Question 11

Phagocytes

Answer 11

cause death of neutrophils

Question 12

Circulating Granulocyte Pool

Answer 12

circulating in blood

Question 13

Marginal Granulocyte Pool

Answer 13

adheres to wall of capillaries

Question 14

Shift to Left

Answer 14

increased demand/ release of immature neutrophils from bone marrow

Question 15

Causes Left Shift

Answer 15

Acute infections (bacterial)
Acute inflammation and tissue necrosis
leukemia

Question 16

Reactive Leukocytosis

Answer 16

leukemia like, but not leukemia
very high neutrophil count (50k+)
response to infection

Question 17

Reactive Leukocytosis can be easily confused with….

Answer 17

Chronic Myelocytic Leukemia (CML)

Question 18

Causes of Neutropenia

Answer 18

Drugs
infection
leukemia

Question 19

Leukemia can be indicated by….

Answer 19

very low neutrophil count

Question 20

Lymphocytes

Answer 20

mononuclear cells derived from lymphoblasts
drive humoral (B cell) and cell mediated (T cell) immunity

Question 21

Causes of Lyphocytosis

Answer 21

acute viral infections

lymphocytic leukemia

Question 22

Causes of Lymphocytopenia

Answer 22

leukemia

Question 23

Diagnosing Neoplastic Disorders of Leukocytes

Answer 23

bone marrow biopsy

Question 24

Diagnosing Lymphomas

Answer 24

lymph node biopsy

Question 25

Signs of Leukemia

Answer 25

anemia | bleeding

Question 26

Symptoms of Leukemia

Answer 26

night sweat

Question 27

Diagnostic Test for Leukemia

Answer 27

Complete Blood Count (CBC) | bone marrow aspirate

Question 28

CML consists of....

Answer 28

myelos and mature neutrophils

Question 29

CLL consists of ....

Answer 29

mature lymphocytes

Question 30

CML can transition to....

Answer 30

AML

Question 31

Acute Lymphocytic Leukemia | ALL

Answer 31

most common leukemia in children B cell >20% lymphoblasts in blood and marrow WBC very high or low (200k+ or 2K-)

Question 32

Diagnostic for ALL

Answer 32

Tdt

Question 33

Acute Myeloid Leukemia | AML

Answer 33

most common acute leukemia in adults >20% blasts in marrow WBC very high or low (200k+ or 2k-) Auer Rods

Question 34

Chronic Myeloid Leukemia | CML

Answer 34

``` adults Philadelphia chromosome elevated WBC (50 - 300k), immature and mature neutrophils ```

Question 35

Treatment for CML

Answer 35

Gleevec

Question 36

Chronic Lymphocytic Leukemia | CLL

Answer 36

``` most common leukemia adults elevated WBC (20k+) lymphocytosis (75%+ of WBC) discovered accidentally ```

Question 37

Treating CLL

Answer 37

watchful waiting; harsher to treat than act early

Question 38

Lymphomas

Answer 38

20s or 50s | painless swollen lymph nodes

Question 39

Diagnostic for Hodgkin's Lymphoma

Answer 39

Reed-Sternberg Cells

Question 40

Does Hodgkin's or non-Hodgkin's have a better prognosis?

Answer 40

Hodgkin's

Question 41

Multiple Myeloma

Answer 41

plasma cells replace bone marrow | causes bone microfractures in lower back

Question 42

Diagnostic of Multiple Myeloma

Answer 42

Bence-Jones protein