Mechanism of Action: Old Way of Thinking - Lipophilic Action Flashcards Preview

Apex 4 - 5 Volatile Anesthetics II: Pharmacodynamics (11) > Mechanism of Action: Old Way of Thinking - Lipophilic Action > Flashcards

Flashcards in Mechanism of Action: Old Way of Thinking - Lipophilic Action Deck (14)
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1

The Meyer-Overton rule states:

Study on!!!!

2

The old theory of anesthetic action suggested that anesthesia was produced by the interaction between the anesthetic agent and the

lipid bilayer

3

The old theory of anesthetic action suggested that anesthesia was produced by the interaction between the anesthetic agent and the lipid bilayer. Even though our understanding of anesthetic action has moved well beyond this simplistic  explanation, we believe this is still critical information that you should know

Bring it on!!!

4

The ----- rule states that lipid solubility is directly proportional to the potency of an inhaled anesthetic

Meyer-Overton rule

5

The Meyer-Overton rule states that lipid solubility is directly proportional to the potency of an inhaled anesthetic. Said another way, the greater the lipid solubility, the ----- the MAC value

"lower"

6

This Meyer-Overton rule implies that the depth of anesthesia is determined by the number of anesthetic molecules that are ----- in the brain
 

"dissolved"

7

This Meyer-Overton rule implies that the depth of anesthesia is determined by the number of anesthetic molecules that are dissolved in the brain and not necessarily the ----- that is used

"particular anesthetic agent"

8

This theory implies that the depth of anesthesia is determined by the number of anesthetic molecules that are dissolved in the brain and not necessarily the particular anesthetic agent that is used. Indeed, a wide variety of ----- agents can produce anesthesia

"dissimilar"

9

The ----- states that all anesthetics share a similar mechanism of action, but each may work at a different site

Unitary hypothesis

10

The Meyer-Overton rule states:

Lipid solubility is directly proportional to potency

11

From the Apex question:

The ----- states that lipid solubility is directly proportional to the potency of an inhalation anesthetic. While it is true that decreased body temperature reduces anesthetic requirements, this is not the Meyer-Overton rule

Meyer-Overton rule

12

From the Apex question:

The ----- states that all anesthetics share a similar mechanism of action, but each may work at a different site.

Unitary hypothesis

13

From the Apex question:

Which theory suggests that inhalation anesthetics interact with stereoselective receptors.

Modern anesthetic theory

14

References:

 

Hemmings. Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application. 1st ed. 2013. p. 161. Nagelhout. Nurse Anesthesia. 6th ed. 2018. p. 81-82.