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Semester 5 November > Med Biochem > Flashcards

Flashcards in Med Biochem Deck (3)
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Why do diabetics get dehydrated?

- high glucose levels in plasma exceeds renal threshold
- glucose not reabsorbed from renal tubules and appears in urine
- glucose in tubules increases osmotic pressure of the filtrate, increasing the amount if water associated with the urine
- increased urine excretion

1

How does tissue damage occur in diabetes

- consistently elevated plasma glucose leads to glucose oxidation and linkage of glucose to plasma proteins
- results in altered protein function

2

Origin of high glucose levels in plasma of diabetics

- plasma glucose not taken up by tissues because glut 4 not activated
- liver stimulated to activate gluconeogenesis