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Semester 5 November > Virology > Flashcards

Flashcards in Virology Deck (42)
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Viral injury to CNS occurs by either

Cytolitic replication
Immunopathology

1

Defn aseptic meningitis

Clinical/lab evidence of meningitis with neg bacterial culture

2

Common causes of aseptic meningitis

Enteroviruses
Mumps

(RARE -HSV2)

3

Histology of post infectious encephalomyelitis (ADEM)

Lymphocytic infiltrate
Peri vascular cuffing of adjacent blood vessels

4

Lesions seen in ADEM

White matter lesions
NB molecular mimicry to myelin (T cell destroys)

5

Cause of post infectious encephalomyelitis

Almost all viruses
Post vaccine

6

Lesions seen in encephalitis

Grey matter lesions

7

Signs in encephalitis

Fever
Drowsy
Decreased consciousness
Focal signs
Confusion
Convulsions

8

Common causes of encephalitis

Herpes simplex
Rabies
Arboviridae

9

Pathogenesis of acute flaccid paralysis

Enter via gut. Bloodstream. Cell bodies of motor neurons = grey matter lesions

10

Spread of measles

Reap droplets

11

Vaccine for measles

Live attenuated vaccine
Not earlier than 9 months = mother IgG prevents vaccine replication

12

Who doesn't get measles vaccine

Pregnant
Severely immunocomprimsed
(<1 year)

13

Possible syndromes from measles in CNS

Acute Measles Post infectious encephalitis
Measles inclusion bodies (immunocomprimsed)
SSPE

14

Spread of mumps

Resp droplets

15

Distinguishing feature of mumps

Parotitis

16

Period of aseptic meningitis in relation to parotitis in mumps

One week before to three weeks after

17

What may follow aseptic meningitis in mumps

Encephalitis

18

Vaccine for mumps

Live attenuated
Not in SA

19

What is seen in 25% post pubertal men in mumps

Orchitis (may lead to infertility)

20

How to diagnose mumps

Serology
Culture saliva/urine
PCR

21

Is it useful to do PCR in post infectious encephalomyelitis

No. Immune reaction so no virus in CSF

22

Spread of enteroviruses

Fecal oral

23

What do enteroviruses most commonly cause in CNS

Aseptic meningitis
Acute flaccid paralysis

24

Three clinical outcomes of polio

Asymptomatic
Minor febrile illness
Major illness - Acute flaccid paralysis
- aseptic meningitis
- respiratory paralysis

25

Diagnosis of polio

PCR
Culture

26

Vaccine for polio

Live attenuated oral (IgA)
Formalin Inactivated (IgG)

27

Why six doses of polio virus vaccine

Only one strain 'takes' each time

28

Four ways viruses can enter CNS

Anterograde neuronal transport
Retrograde neuronal transport (rabies, HSV)
Trojan horse by lymphocyte/ macs cell lines (west Nile, HIV)
Infection of endothelium in blood vessels in BBB

29

Post exposure prophylaxis for rabies

Rabies Ab
Rabies vaccine