Memory and Dementia Flashcards

1
Q

What can cause a short term memory loss?

A

Alcohol, head trauma etc

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2
Q

Two different types of amnesia?

A

Retrograde or anterograde

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3
Q

Retrograde amnesia?

A

Lose ability to recall memories that have already been learned

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4
Q

Anterograde amnesia?

A

Cant create new memories

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5
Q

What are demetias?

A

A family of symptoms characterized by a decline in cognitive functions sufficient to cause impairment in social and occupational performance

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6
Q

What is the first presenting feature of demetia?

A

Decline in memory

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7
Q

Most common form of dementia?

A

Alzheimers

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8
Q

What are initiation deficits/apathy?

A

Lacking the will to do something

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9
Q

What are visuo-spatial deficits?

A

Forgetting visual things/locations e.g. forgetting the way home/where they are etc

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10
Q

Most common alzheimer’s symptoms?

A

Memory, initiation, visuo-spatial and language deficits

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11
Q

Paraphasia?

A

Struggling to identify the right words

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12
Q

What drives executive function?

A

Frontal cortex

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13
Q

What is executive funciton?

A

Risk assessment–> motivated to do x thing but there may be a risk, weighing up pros and cons

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14
Q

Symptoms of having executive function issues?

A

V risk averse/v risky

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15
Q

What is psychosis?

A

A psychotic epidose–> is a symptom not a disease itself

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16
Q

Does psychosis occur in AZ?

A

Yes

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17
Q

How is psychosis treated in AZ?

A

Antipsychotics that are used to control schizophrenia

18
Q

Incidence of AZ with age?

A

Strongly correlated with age

19
Q

Cause of AZ?

A

Neurons in the brain dying

20
Q

Where is the first locus of AZ damage?

A

Temporal lobes

21
Q

What is found in the temporal lobes?

A

Hippocampus and entorhinal corex

22
Q

Why are memory deficits seen as the first symptoms of AZ?

A

FIrst affected parts are hippocampus and entorhinal cortex which are involved in memory

23
Q

What happens to the rest of the brian as AZ spreads?

A

AZ spreads around the brain

24
Q

Which parts of the brain are not affected by AZ?

A

Midbrain/brainstem

25
Cause of AZ?
Extracellular plaques that form as a result of abnormal beta amyloid, and intracellular tangles made up of abnormal Tau protein
26
Where is APP found?
Membrane spanning
27
First action on APP?
Cleaved by alpha secretase
28
What forms as a result of alpha secretase cleaving APP?
APP alpha (soluble)
29
What effects does APP alpha have?
Trophic--> positive ("nourishes the neurons")
30
What happens to the rest of APP that isn't cleaved into APP alpha?
Cleaved by gamma secretase into two smaller peptides that can be metabolised
31
What happens to APP in AZ?
It gets cleaved by beta secretase
32
Difference between alpha and beta secretase?
Cleavage position on APP
33
What forms as a result of beta secretase cleavage of APP?
APP beta, and a larger peptide remnant
34
What cleaves the larger protein remnant formed by beta secretase cleavage?
Gamma secratase
35
What forms as a result of gamma secretase cleaving the larger peptide remnant from beta secretase?
Beta amyloid 40 or beta amyloid 42
36
How is ApoE4 involved in AZ?
It can help beta amyloid 40/42 form plaques
37
General role of ApoE4?
Helps cholesterol and fat soluble vitamins enter neurons
38
What can beta amyloid plaques do?
Drive production of phosphorylated Tau
39
What % of AZ cases are sporadic?
90%
40
What may cause the formation of amyloid beta 40/42?
Enhancement of beta secretase as a result of environmental/disease/inflammation
41