Neuropeptides III

Question 1

Classes of opioid receptor?

Answer 1

Mu, delta, kappa

Question 2

Mu opioid receptor ligand?

Answer 2

• B-endorphin, met-enkephalin

Question 3

Kappa opioid receptor ligand?

Answer 3

Dynorphins

Question 4

Delta-opioid receptor ligand?

Answer 4

Leu-enkephalin

Question 5

What do the opioid receptors signal via?

Answer 5

Inhibitory g protein

Question 6

Result of opioid receptor signaling?

Answer 6

Modulation of NT release by regulation of K+ and Ca2+ channels using beta gamma g protein subunit

Question 7

How do opioid receptors modulate the K+ and Ca2+ channels?

Answer 7

Via release of the beta gamma subunit which associates with the channel to regulate its channel opening

Question 8

What is biased agonism?

Answer 8

Activity at the receptor can specify which downstream signalling pathway should be used

Question 9

How are neurotrophins generated?

Answer 9

Via transcription

Question 10

What do neurotrophins regulate?

Answer 10

Growth, survival and differentiation within the brain

Question 11

Neurotrophin size?

Answer 11

120 AAs

Question 12

What type of signalling is seen more in neurotrophin compared to neuropeptides?

Answer 12

Paracrine-like

Question 13

Main neurotrophins?

Answer 13

Nerve growth factor and brain-derived neurotrophic factor

Question 14

Which receptors do nerge growth factor and BDNF bind?

Answer 14

TrkA, TrkB

Question 15

What type of receptor are TrkA and TrkB?

Answer 15

RTKs

Question 16

Affinity of RTKs?

Answer 16

V high–> higher than neuropeptide receptors