METHYLPREDNISOLONE SODIUM SUCCINATE (SOLU-MEDROL)

Question 1

CLASS

Answer 1

• STEROID
• GLUCOCORTICOID
• ANTI-INFLAMMATORY

Question 2

ACTIONS

Answer 2

• ANTI INFLAMMATORY BY STABILIZING MAST CELL/LYSOSOMAL MEMBRANES
• DECREASE CAPILLARY PERMEABILITY
• RELIEVES EDEMA OF SPINAL CORD TISSUE (THEORETICAL
• POTENTIATES VASCULAR SMOOTH MUSCLE RELAXATION BY BETA 2 AGONISTS (BRONCHODILATION)

Question 3

INDICATIONS

Answer 3

• SPINAL CORD TRAUMA
• STATUS ASTHMATICUS
• EXACERBATION OF COPD
• ANAPHYLAXIS

Question 4

DOSAGE/ ROUTE

Answer 4

SEE HAWAII SO

Question 5

STANDARD PREP

Answer 5

1 GM IN 8 CC ACT-O-DOSE VIAL, 125 MG/2CC

Question 6

PEDS DOSE

Answer 6

ASTHMA/ANAPHYLAXIS = 1-2MG/KG IV

Question 7

SIDE EFFECTS

Answer 7

• MOST SERIOUS EFFECTS ARE FROM CHRONIC STEROID USE AND INCLUDE HTN, SODIUM AND WATER RETENTION (MOON FACE), PROLONGED WOUND HEALING, SUPPRESSION OF ADRENOCORTICAL, STEROID PRODUCTIONS, GASTRIC ULCER ( GI BLEDDING), PAPER THIN SKIN EASILY TORN, REACTIVATION OF HEALED TB.

Question 8

PRECAUTIONS

Answer 8

• DISPOSE ACT-O-DOSE VIAL AFTER USING SINCE MIXTURE IS ONLY GOOD FOR 48 HRS AFTER MIXING.
• ONSET OF ACTION IS 2-4 HRS.