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Flashcards in Misc. Problems Deck (33):
1

when is the full antithrombotic effect of warfarin seen?

5-7 days

2

what should be used in place of warfarin in pregnant women?

heparin

3

benefit of LMWH

doesn't require coontinuous monitoring of the PT time

4

when can heparin be d/c (when overlapped with warfarin)

once the INR is >2.0 on at least 2 consecutive days

5

when is warfarin best taken

on an empty stomach at a specific time each day , administration at bedtime works well

6

once stabilized how often an INR be checked

every 3-4 weeks

7

what is the target INR for most patients

2.0-3.0

8

how to reverse INS of less than 10 rapidly

oral vitamin K (faster than subQ vitamin K) about same speed as IV vitamin K

9

how to reverse and INR of >20

fresh frozen plasma

10

how to change warfarin dose before elective surery

have them stop 4 days before so INR drops to around 1.5

11

what should be avoided w/ warfarin

NSAIDs and excessive amounts of alcohol

12

when is biopsy appropriate in LAD

if an abnormal node hasn't resolsved after 4 weeks and patient has other findings w/ malignancy- fever, night sweats, weight loss

13

what does left supraclavicular adenopathy suggest (Virchow's node)

abdominal malignancy

14

what does right supraclaviular adenopathy suggest

cancer in the mediastinum, lungs, esophagus

15

what are common causes of axillary LAD

cat scartach dz, infections, breast cancer , silicone breast inplants

16

causes of generalized LAD

HIV, tuberculosis, mono, LE

17

common causes of edema

heart failure, cirrhosis, nephrotic syndrome

18

PE with pulmonary edema

tachypneic, diaphoretic patient with wet rales, and possibly a diastolic gallop (s3) and heart murmurs

19

patient with nephrotic syndrome may havew hat kind of edema?

periorbital

20

what does nonpitting peripheral edema suggest

lymphatic obstruction or hypothryoidism

21

causes of nonpitting edema

lyphemedma, pretibial myxedema (thyroid dz)

22

presents with decrease platelet levels and is mediated by the production of IgG autoantibodies directed against platelets. PE findings are normal, may have slightly enlarged spleen

Idiopathic thrombocytopenic purpura

23

disorder that results in clotting of the small blood vessels from spontaneous platelet aggregation. The clots formed can be damaging since they can interfere with the proper flow of blood to the body’s vital organs. People with this type of disorder have insufficient amounts of enzymes necessary in inhibiting a blood clotting protein.

thrombocytic thrombocytopenic purpura

24

symptoms with TTP

confusion, tachy, weakness, fever

25

Tx for ITP

prenisone of IVIG, many adult require spenlectomy

26

tx for TTP

corticosteroids and plasmapharesis

27

what is seen on blood smear with DIC

schistocytes

28

what lab with elevated with hemophilia A

aPTT

29

Hemophilia A is a deficiency in what?

Factor VIII

30

what will be elevated with a Vitamin K deficiency?

PT

31

what is factor VIII concentrate used for?

hemophilia A

32

tx for vWF deficiency

intranasal desmopressin

33

what causes anemia with a high reticulocyte count

acute blood loss