Missed questions Flashcards
(177 cards)
Drugs that cause folic acid deficiency
Phenytoin
Trimethoprim (dihydrofolate reductase)
Methotrexate (DHFR) leucovorin rescue
Pruritis after shower, dizziness, headache, HTN, facial plethora, hypercellular BM
PCV
- Primary = LOW EPO, JAK2 mutation
- Secondary = Normal/high EPO, hypoxemia, renal tumor, hepatic tumor, testosterone replacement
- can precipitate GOUT attack
Immune-mediated drug reaction by captopril
Membranous GN
35 weeks gestation, HTN, dec urinary output, thrombocytopenia
Preeclampsia w/ severe features (pul edema, LFTs, SBP >160, inc Cr) –> hydralazine or labetalol then mag sulfate
93 y/o vaginal bleeding, odor, mass, no mets
SCC –> resect 2cm or poor surgical candidate
Combination chemotherapy stage III, IV
High non-response rate, use only hospital-based patients, loss of study patients type of bias
Selection bias
Improves mortality in CHF
ACE, BBs, spironolactone
Exudative pleural effusions
Protein >0.5, LDH >0.6 that of normal
Infection, auto-immune, neoplasm
INC CAPILLARY PERMEABILITY
Low TSH, high T4, T3, no signs of Grave disease, low RAIU
Facticious or exogenous thyrotoxicosis = LOW serum thyroglobulin
Low TSH, high T4, T3, no signs of Grave disease, high RAIU
Diffuse = Grave Nodular = toxic adenoma or mulitnodular goiter
Tachycardia with buried P-waves, chest pain, diaphoresis, normal BP, hx anxiety, dizziness
SVT = Adenosine
Bone pain, difficulty walking, cramps, pseudofractures
Osteomalacia = INC PTH, alk phos + LOW Ca, phos, 25D-OH
- malabs, chronic liver, kidney, intestinal bypass, celiac
- # 1 = vit d deficiency
Fever, back pain w/ local tenderness, recent UTI, NO leukocytosis, INC ESR/CRP, normal x-rays
Osteomyelitis –> MRI –> CT guided aspiration
White edematous retina following retinal arterioles, curtain falling over eye
Retinal emboli –> carotid doppler
Painless loss of vision, boxcar segmentation, cherry fovea, pallor or hyperemic disc
CRAO
Mallory bodies and neutrophilic infiltrate on liver bx
Alcoholic hepatitis = completely reversible w/ etOH cessation
Regenerative nodules = cirrhosis = irreversible
Encapsulated yeast
Cryptococcus neoformans = amphotericin B + flucytosine –> fluconazole for 1 yr
Itraconazole does NOT cross BBB
DOC for Lyme disease < 8/yo
Amoxicillin or cefuroxime
HIV pt, pancytopenia, palatal ulcers, hepatosplenomegaly, intetstitial pneumonitis
Histoplasma
New DOE, swelling of head, neck, arms, plethora of face, no LE edema, ascities
SVC syndrome –> CXR for NHL or lung CA
DVT –> heparin therapy –> 6th day new right sided weakness, aphasia, 50,000 platelets, skin necrosis, normal CT, heart RRR, no fibrin split products
HIT type 2 (antibody platelet activation)
- –> binds PF4 –> IgG –> activates Fc receptor leading to platelet activation
- –> ARTERIAL or venous THROMBOSIS
HIV esophagitis work-up
- Candida –> oral fluconazole
- esophagoscopy + bx, cytology, culture w/o improvement
HSV = round/ovoid ulcers + perioral ulcers CMV = linear ulcers
Common findings in anorexic patients
- Osteoporosis
- Elevated cholesterol and carotene
- Prolonged QT
- Euthyroid sick syndrome
- HPA axis - amenorrhea, anovulation, dec estrogen
- HypoNa
- Small for gestational age baby, intellectual impairment, miscarriage, depression, hyperemesis, c/s
Southern US + tick bite + thrombocytopenia + leukopenia, fever, malaise, inc LFTs, inc LDH, intracytoplasmic morulae
Ehrlichiosis –> doxycycline