Flashcards in MOD S11 - Incomplete Neoplasia III Deck (7)
What is retinitis pigmentosum?
Confers an increased risk of skin cancers when exposed to UV rays in sunlight
What is ataxia telangiectasia?
Defective response to radiation damage
Profound weakness to lymphoid malignancies
Usually die before 20
What is Fanconi's anaemia?
Sensitivity to DNA cross linking agents
Marrow hypo function
Multiple congenital abnormalities
Predisposition to cancer
Through what gene is familial adenomatous polyposis inherited?
Name a gene mutation which increases susceptibility to breast cancer
BRCA1 and BRCA2
Through what gene is Li Fraumeni syndrome inherited?
The gene for p53