MOD S11 - Incomplete Neoplasia III Flashcards Preview

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Flashcards in MOD S11 - Incomplete Neoplasia III Deck (7)
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1

What is retinitis pigmentosum?

Confers an increased risk of skin cancers when exposed to UV rays in sunlight

2

What is ataxia telangiectasia?

Defective response to radiation damage
Profound weakness to lymphoid malignancies
Usually die before 20

3

What is Fanconi's anaemia?

Sensitivity to DNA cross linking agents
Marrow hypo function
Multiple congenital abnormalities
Predisposition to cancer

4

Through what gene is familial adenomatous polyposis inherited?

APC

5

Name a gene mutation which increases susceptibility to breast cancer

BRCA1 and BRCA2

6

Through what gene is Li Fraumeni syndrome inherited?

The gene for p53

7

Give examples of genetic conditions which increase the risk of tumours

Retinitis (xeroderma) pigmentosum
Ataxia telangiectasia
Fanconi's anaemia