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DMD 1 Sem 1 > Module 1 > Flashcards

Module 1 Flashcards

(115 cards)

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1
Q

Mutation of what cause DI usually?

A

DSPP

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2
Q

Regional odontodysplasia (ghost teeth) is more prevalent in what gender & teeth

A

Female, Max. anterior

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3
Q

List the correction order of tooth dvlpment stages

A

Initiation > bud > cap > early bell > late bell

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4
Q

Mineralisation start @_______stage

A

Late bell

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5
Q

Dental papilla & dental follicle formed @_______stage

A

Cap

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6
Q
  • Stellate reticulum (SR) forms @_______stage
  • Enamel Knot forms @________stage
A
  • Cap
  • Cap
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7
Q

IEE & OEE forms @_______stage

A

Cap

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8
Q

What is the fxn of stellate reticulum (SR)

A

Connects & maintain shapes of dental organs

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9
Q

Oral epithelial cells lose tooth forming capacity by week___in utero ?

A

11

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10
Q

Which 2 things happen during bud stage ?

A

Epithelium cells invagination, NCC condensation

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11
Q

Successional lamina forms @______stage

A

Early bell

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12
Q

Stratum intermedium forms @________stage

A

Early bell

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13
Q

Defects in what stages lead to tooth number anomalities ?

A

Initiation & bud

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14
Q

T/F, All the primary teeth have commenced calcification at birth

A

T

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15
Q

Mutation in______is the most common form of AI ?

A

Enamelin

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16
Q

Which of the following statements regarding dentine is correct?
Pre-dentine is highly calcified

Mantle dentine is adjacent to the dental pulp

Circumpulpal dentine has collagen fibres orientated parallel with the dentino- enamel junction

Mantle dentine has collagen fibres orientated parallel with the dentino-enamel junction

Pre-dentine is adjacent to the dentino-enamel junction

A

Circumpulpal dentine has collagen fibres orientated parallel with the dentino- enamel junction

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17
Q

Which of the following is secreted at mineralising front with a high affinity for calcium and hydroxyapatite surfaces?

Matrix vesicle

Enamelin

Epitaxy

Dentine phosphoprotein

Amelogenin

A

Dentine phosphoprotein

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18
Q

A history of acute infection of a newly erupted permanent lateral incisor tooth is most consistent with a diagnosis of:
Dentinogenesis imperfecta

Dens invaginatus

Amelogenesis imperfecta

Dentinal dysplasia

Dens evaginatus

A

Dens evaginatus

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19
Q

Preparing a tooth cavity for a restoration could stimulate all of the following actions EXCEPT

Death of odontoblasts

Sclerotic dentine formation

An increase in the number of dentinal tubules

Irregular dentine formation

Dead tract formation

A

An increase in the number of dentinal tubules

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20
Q

Which of the following statements on histological feature of a mature tooth is correct?
The dentino-enamel junction is scalloped with peaks directed away from the pulp

The dentino-enamel junction is scalloped with peaks directed towards the pulp

Odontoblast processes branch mostly at the pre-dentinal junction

The dentino-enamel junction is straight

Odontoblastic processes do not branch

A

The dentino-enamel junction is scalloped with peaks directed AWAY the PULP

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21
Q

The functions of maxillary incisors include the following, EXCEPT:
Aesthetics
Guiding the movement of the jaw
Grinding food
Phonetics
Cutting food

A

Grinding food

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22
Q

Which of the following helps remove the inhibition of mineral deposition in the maturation phase of amelogenesis?
Enamel matrix serine proteinase 1

Dentin phosphoprotein

Enamelin

Tuftelin

Epitaxy

A

Enamel matrix serine proteinase 1

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23
Q

Which of the following proteins self-assembles into nanospheres which act as spacers to allow the crystals to grow during enamel maturation?

Ameloblastin

Tuft protein

Enamelin

Enamelysin

Amelogenin

A

Amelogenin

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24
Q

(Lamelle/spindles/tufts) are twisted ?

A

Tufts

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25
Dentinal TUBULES enables________?
Diffusion of nutrients & sensation via nerves
26
 Cell bodies of odontoblast is found in which part of the tooth ? 
The pulp
27
______is the second hardest tissue in the body ?
Dentine
28
Dentine contains __% mineral (Ca Hydroxyapatite)
70
29
T/F, enamel contains collagen ?
F
30
Distal region of ameloblast produce_____?
Rod Enamel
31
Proximal region of ameloblast produce ?
Interod Enamel
32
Enamel interrod crystals are oriented______ ?
Obliquely
33
In enamel rods, crystals are oriented_______
Longitudinally WITHIN rod
34
The diameter of enamel rod is about_____?
4 um
35
enamel rod & interrod meet at_______?
Rod sheath
36
What tooth are accessional ?
The 3 molars 
37
What are the 2 patterns of concrescence ?
- Dvlpmental/Post inflammatory
37
Successional permanent tooth derive from_____?
Successional lamina
38
Cervical enamel extension is common in______________
Buccal surface of mandibular molar, 3rd molar
39
Where is cusp of carabelli found ?
mesiolingual of maxillary molar
40
What are the 3 types of Amelogenesis Imperfecta
Hypoplastic, Hypocalcified, Hypomaturated
40
DD1 or DD2 is due to defects in coronal dentine
DD2
40
What are the 3 common accessory cusps ?
Cusp of Carebelli, Talon cusp, Dens Evaginatus
40
What is a talon cusp ?
xtra cusp on anterior teeth, more commonly permanent upper central & lateral incisors
41
Dens Evaginatus is found in ?
Premolar/Molar, more commonly in mandible. usually bilateral
42
Enamel pearl is commonly found in_______
upper perm. molars
43
Cervical enamel extension is commonly found in________
lower molars, particularly 3rd molars
44
Concrescence is the fusion of two adj teeth by (cementum/dentine) ?
cementum
45
List 4 clinical symptoms of hypoPLASTIC smooth amelogenesis imperfecta 
- Thin enamel - Chisel like on incisor - Lost of occlusal surface - Big spacing between teeth
46
- Gardner's syndrome is due to______mutation - List 4 symptoms
- APC (tumor supressor gene) - Impacted/Supernumerary teeth, polyps in colon, tumors, multiple jaw osteomas
47
List 3 clinical symptoms of hypoCALCIFIED amelogenesis imperfecta
- Very soft and chalky tooth - High protein content - Yellow/Brown discoloration
47
List 3 clinical symptoms of hypoPLASTIC rough amelogenesis imperfecta
- Thin enamel - Crowns maybe shaved off in some teeth - Black depositions on teeth
48
List the clinical symptoms of hypoMATURATED amelogenesis imperfecta
- Brittle & enamel chipping - inner enamel is LESS mineralized than surface enamel
49
Odontoblast derive from________
NCC
50
T/F, dentine is not living tissue ?
F
51
Ameloblast secrete enamel matrix thru__________process
Tomes'
52
Enamel is_______% mineral
96
53
Lamellae extends from_______to________
Enamel surface to DEJ
53
HSB (Hunter-Schreger Bands) are caused by___________
bundles of fully mineralised rods following twisted path thru enamel layer
54
Tufts extend from__________to___________
DEJ to enamel
54
Spindles extend from__________to__________
DEJ to enamel
54
In ground section, HSB is seen extending__________
inner 2/3rds of enamel layer
55
Initiation stage of tooth dvlpment run between week___________
6 to 11
56
Dental lamina is formed @ what stage
Initiation
57
The Amelogenin locus is found on the X chromosome. Amelogenesis imperfecta is a mutation of this gene that can affect both males and females. What inheritance pattern does this disease follow? X-linked recessive X-linked dominant Autosomal dominant Autosomal recessive Mitochondrial heredity
58
Which of the following structures is primarily responsible for extending through the dentinoenamel junction INTO the enamel during tooth development? Perikymata Reduced enamel epithelium Enamel spindles Enamel tufts Enamel lamellae
Enamel spindles
59
Which type of dentine formation is ongoing at the completion of root development
Secondary
60
The hardness of dentine increases with age is mainly due to the increase of
Peritubular dentine
61
Which of the following cell types give rise to the dentine-pulp complex? Epiblasts Dental laminar Neural crest cells Stellate reticulum Trophoblasts
Neural crest cells
62
Which of the following statements about the dental follicle is CORRECT? Dental follicle gives rise to cementum and periodontal ligaments Dental follicle cells are derived from the secessional dental lamina Dental follicle does not play any roles in the embryonic staged of tooth formation Dental follicle dictates the shape of the tooth root Dental follicle gives rise to root dentine
Dental follicle gives rise to cementum and periodontal ligaments
63
Which structure provides nutrition for odontoblasts during tooth dvlpment
Dental Papilla
64
What future structures dental follicle give rise
Cementoblast (Cementum), Periodontium (PDL), Osteoblast (Alveolar bone)
65
Dental lamina degrade & lose connection w/ oral epithelium at_________stage
Late bell
66
_____________becomes Cell Rests of Serres
Remnants from disintegration of dental lamina connecting to oral epithelium at late bell stage
66
__________initiates radicular dentine formation ?
HERS
67
Reciprocal induction initiates @ the_______side of tooth
Lateral
68
Short-term incremental lines is the result of_________
daily enamel pdtion
68
Long-term incremental lines (striae of retzius) is the result of_______
Long term rhythms in enamel pdtion
68
What forms perikymata
Striae of retzius meet the tooth surface forming ridges
68
(Lamelle/Tufts/Spindles) are trapped ends of odontoblast process ?
Spindles
69
Cell body of odontoblast remain in______, odontoblastic process extends inside dentinal tubules into________
Pulp, DEJ
69
ODONTOBLAST produce ORGANIC MATRIX called________, which is then____________
pre-dentine, mineralized into dentine
69
(Enamel/Cementum) forms first
Enamel
69
Each dentinal tubule is surrounded by a region of MORE highly mineralized matrix called_____________
Peritubular dentine
69
________dentine is produced first & adj to DEJ
Mantle
70
_________dentine forms the bulk of dentine & tooth
Primary
70
Dentinal tubules exhibit_________branching, which enhances__________
Lateral, communication
71
__________dentine deposits locally as part of reparative process
Tertiary
72
_________dentine surrounds periphery of pulp chamber & lay down dentine @ slower rate later in life
Secondary
73
________dentine forms during dvlpment of tooth
Primary
73
_________dentine forms after root formation & eruption
Secondary
74
There is a change in course between which dentines
Between Primary & Secondary
75
________dentine can be asso w/ some dz & may allow for faster spread of dz
Interglobular
76
Diurnal line is the result of_________
daily pdtion of dentinal matrix & change in collagen fiber oritentation
76
Diurnal line run (parallel/perpendicular) to tubules
perpendicular
77
5 days line is the result of
longer term incremental pdtion of dentine in a 5 day cycle
78
Enamel is produced @____um per day
4
78
Dentine matrix is deposited @____um per day
4
79
What does enamel's protein matrix consist of
Enamelin, Amelogenin, Ameloblastin, Tuftelin
79
Oligodontia happens when_______teeth missing
> 6
80
Mutation in________ is most likely to cause oligodontia
AXIN2
80
Hypodontia is most frequently caused by mutation in what gene
Ectodysplasia A
81
What does dentine's protein matrix consist of
Collagen 1, DSPP (Non-collagenous)
82
Hypodontia is mostly autosomal (dominant/recessive)
dominant
83
What teeth are most likely to be missing in hypodontia
3rd molars, 2nd pre molars, max. lateral incisors
83
Congenital malformation means anomalies occur during______________
Dvlpmental stages
84
List 6 symptoms of Cleidocranial Dysplasia
1. Clavicles missing 2. Mand. protrusion 3. Max. Micrognathism 4. Frontal skull protrusion 5. Supernumerary teeth 6. Fail to erupt
84
Cleidocranial Dysplasia is caused by mutation in________
RUNX2
84
T/F, Amelogenesis imperfecta is autosomal dominant
F, can be autosomal dominant, autosomal recessive, X-linked dominant
85
- Dentinogenesis Imperfecta 1 is caused by mutation in_______gene - What is the inheritance pattern
- Collagen - 80% autosomal dominant,
86
- Dentinogenesis Imperfecta 2 is caused by mutation in_______gene - What is the inheritance pattern
- DSPP - Autosomal dominant
87
Mutation in what stages lead to size/shape anomalies
Cap, early bell
88
Mutation in what stage lead to mineralization anomalies
Late bell
89
Which ones are not successional teeth
the 3 perm. molars
90
HERS is made up of_____________
Apical OEE & IEE w/out Stellate Reticulum & Successional Lamina

DMD 1 Sem 1 (12 decks)

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