MODULE 6 PART 3.1: PHASE 1 METABOLISM

Question 1

Drug will undergo three different reactions. What are these?

Answer 1

1. Oxidation
2. Reductive deamination (reduction)
3. Hydrolysis

Question 2

(1) It is the ____ that is broken down into small fragments/vesicles known as microsome.

Answer 2

SER

Question 3

(2) SER fragments can produce enzymes called ____.

Answer 3

cytochrome

Question 4

(3) Give some examples of cytochrome enzymes.

Answer 4

1. p450
2. p488
3. b5

Question 5

(4) Cytochrome enzymes mixed with oxygen results in ?

Answer 5

Mixed-function oxidase (MFO)

Question 6

(5) What is the function of mixed-function oxidase?

Answer 6

• Oxidation
• Hydrolysis

Question 7

(6) Cytochrome enzymes mixed with NAPDH will result in ?

Answer 7

• NADPH + cytochrome c reductase = hydroxylation (hydrolysis)

Question 8

(7) Outer layer of mitochondria has ______ ______ enzyme.

Answer 8

monoamine oxidase

Question 9

(8) What is the function of monoamine oxidase?

Answer 9

• Oxidation
• Reduction/deamination of biogenic amine

Question 10

(9) Hydrolysis is important metabolic pathway for _____ and _____.

Answer 10

ester-linkage; amide-bond

Question 11

(10) What are the enzymes for hydrolysis?

Answer 11

• Amidases - soluble fraction of the liver
• Esterases - plasma