MODULE 6 PART 3.2: PHASE 2 METABOLISM

Question 1

What is the most important metabolic pathway for endogenous compound?

Answer 1

Glucoronic acid/glucoronide

Question 2

Non-polar metabolite can be conjugated with 4 compounds. What are these?

Answer 2

• Glucoronic acid
• Methionine
• Sulfate
• Acetate

Question 3

Non-polar metabolite to glucoronic acid/glucoronide conjugation requires what enzyme?

Answer 3

Glucoronyl transferase

Question 4

Non-polar metabolite to sulfate conjugation requires what enzyme?

Answer 4

Phenosulfotransferase

Question 5

Non-polar metabolite to acetate conjugation requires what enzyme?

Answer 5

Arylamine acetyltransferases

Question 6

Sulfate conjugation is important for metabolism of _____ and ____.

Answer 6

Phenol and aliphatic alcohol (e.g. phenol, acetaminophen, morphine, isoproterenol, ascorbic acid)

Question 7

Sulfate conjugation is also needed with ____, _____, and _____.

Answer 7

chondroitin, heparin, and steroid

Question 8

Glucoronyl transferase is absent in what animal?

Answer 8

Cat

Question 9

Arylamine acetyltransferase is absent in what animal ?

Answer 9

Dog

Question 10

Phenol sulfotransferase is absent in what animal?

Answer 10

Pig