1
Q
Systemic Lupus Erythematosis
A
Autoimmune; U1 RNA (snRNP); Sx: extreme fatigue, arthritis, fever, skin rashes, kidney problems
2
Q
Limb girdle muscular dystrophy (LGMD)
A
Calpain 3 mutation causing new splice site w/in Exon 16 -> Splicesome removes Exon 16
3
Q
β-thalassemia
A
Mutation of 1st position of Intron 2; G->A mutations, thus Exon 1 is spliced out; microcytic hypochromic anemia
4
Q
Trypanosomes (Chagas disease)
A
Protozoal DNA causes insertion of U into DNA via terminal uridyltransferase; protozoa edits its own mitochondrial DNA
5
Q
Leishmania (leishmaniasis)
A
RNA editing
