MSK pharm Flashcards
(55 cards)
glucocorticoid (corticosteroid) with strange name
triamcinolone
corticosteroid highlighted action
increase kB which inhibits NF-kB (nuclear transcription factor) which upregulates cox2
tnf a controls nfkb
also inhibits phospholipase a2, which frees arachadonic acid from membrane phospholipids
what coxs are important in the kidney?
cox 1 and 2
where is cox 1?
- kidney
- gi
- platelets
- endothelium
where is cox 2?
- inflammatory cells
- endothelial cells
- kidney
cox 2 makes prostaglandins that are important for?
permeability, pain, fever
leukotriences that increase bronchial tone
LTC4, LTD4, LTE4
leukotrience that attracts neutrophils
LTB4
pgi2
decrease platelet aggregation and vascular tone
txa2
increase platelet aggregation, increase vascular tone
pge2 actions
redness: vasodilation
edema: permeability
fever: hypothalamus
pain: nerves
what can causes acute kidney injry?
uptodate says any class of nsaid
acetaminophen mech
455
acetaminophen use
455
acetaminophen effcts
455
aspirin pharmacology
o order at high/toxic concentration
aspirin can causes CIN and renal papillary necrosis how?
combined with acetomenophin
how to treat aspirin OD
nahco3, it alkalnizes the urine
aspirin mech
456
aspirin effects
aspirin induced asthma, less frequently causes AIN then the other NSAIDS,
celecoxib mech
456
celecoxib use
456
celecoxib effects
456
celecoxib effects
456
