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Pharmacology > tumor genes and such > Flashcards

tumor genes and such Flashcards

(50 cards)

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1
Q

astrocytoma

A

PDGF, overexpression and autocrine loop,

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2
Q

subset of breast carincoma

A

egfr or receptor tyrosine kinase, amplification,

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3
Q

men 2a, 2b, sporadic medullary thyroid cancer

A

RET, egfr or receptor tyrosine kinase, point mutation

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4
Q

GIST

A

kit, stem cell growth factor receptor or cytokine recetpro, point mutation

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5
Q

RAS

A

gtp binding protein or gtpase, colon cancer, lung adenocarcinoma, pancreatic cancer, carcinomas, melanomas, lymphomas

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6
Q

CML and some types of ALL

A

BCR ABL 922

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7
Q

lung small cell carcinoma

A

L-myc, transcription factor, amplification

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8
Q

burkitt lymphoma

A

c-myc, trascritiopn factor, 8 14 heavy chain igh

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9
Q

neuroblastoma

A

n myc, amplificatino, transcription factor

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10
Q

mantle cell lymphoma

A

11 14 (CCND1, cyclind1, cyclin)

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11
Q

melanoma

A

cdk4, amplification, BRAF too

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12
Q

lung adenocarincoma

A

ALK, receptor tyrosine kinase,

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13
Q

follicular lymphoma

A

bcl2

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14
Q

diffuse large b cell lymphoma

A

bcl2

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15
Q

pappilary thyroid cancer

A

BRAF

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16
Q

chronic myeloproliferative disorders

A

JAK2, tyrosine kinase,

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17
Q

colorectal cancer (FAP)

A

APC, negative regulator of the b catenin/wnt pathway

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18
Q

breast ovarian and pancreatice cancer

A

BRCA1/BRCA2, dna repaire protein

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19
Q

melanoma, pancreatice cancer

A

p16, blocks g1 to s phase

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20
Q

DCC

A

colon cancer

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21
Q

DPC

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A

deleted in pancreatic cancer, dpc4/smad4

22
Q

men 1

23
Q

NF1

Study These Flashcards
A

NF1, neurofibromin which is a RAS activating GTPase

24
Q

NF2

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A

merline (schwannomin) protein

25
li fraumeni tumors
SBLA, sarcoma, breast, leukemia, adrenal gland
26
tuberour sclerosis
TSC1 -> hamartin protein, TSC2 -> tuberin protein
27
von hippal lndaue disease
VHL, inhibits hypoxia inducible factor 1a, causes increased vegf and pro;iferation
28
wilms tumor (nephoblastoma)
WT1, transcription factor that regulates urogenital development
29
aflatoxins
aspergillus, stored rice and grains, africa, hepatocellular carcinoma
30
akylating agents
leukemia/lymphoma from cehmotherapy side effects 5-10 yrs down road
31
alcohol
squamous cell carcinoma of oropharynxy and esophagus and heptocellular carcinoma
32
arsenic
skin (sqamous cell carcionoma, women applied to their skin to make lighter), lung cancer (in smoke), and liver angiosarcoma
33
asbestosis
bronchogenic carcinoma > mesothelioma
34
cigareete smoke
bladder -> transitional cell carcionma cervix -> cervical carcionma esophagus -> squamous cell carcinoma/adenocarcinoma kidney -> renal cell carcionoma larynx -> squamous cell carcinoma lung -> squamous cell and small cell carcinoma pancrease -> pancreatic adenocarcinoma
35
nitrosamines
smoked foods, responsible for gastric adenocarincomas in japan
36
aromatic amines (benzidine, 2-naphthylamine)
cig smoke, urothehlial cell carcionoma of bladder
37
vinly chloride
liver angiosarcoma, occupation exposure, used ot make PVC
38
nickel, chromium, berylium, or silica
lung carincoma form occupational exposure
39
CCL4
centrilobular necorisis and fatty change
40
ionizing radiation
pappillary thyroid caricnoma, aml, cml generates hydroxyl free radicals
41
radon
lung cancer
42
EBV
burkitt lympphoma, hoddking lymphoma, nasopharyngeal carcinoma, primary cns lymphoma in immnocompromised
43
HBV, HCV
hepatocellular carcinoma
44
HHV8
kaposi sarcoma
45
hpv
cervical and penile/anal carcionoma (16 18) and head and neck cancers, vulva, vagina
46
h pylori
gastric adenocarcinoma and malt lymphoma
47
htlv1
adult t cell leukemia/lymphoma
48
liver fluke (clnorcchis sinensis)
cholnagiocarcinoma
49
schistosoma hematobium
bladder cancer (squamous cell)
50
nonionizing (uvb sunlight is most common)
basal cell carcinoma, squamous cell carcinoma, melanoma of the skin results in formation of pyrimidine dimers and DNA which are normall excised by restriction endonuclease

Pharmacology (33 decks)

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