MSK/Rheum

Question 1

Anti CCP

Answer 1

RA

Question 2

Anti dsDNA

Answer 2

SLE

Question 3

Anti-Ro, anti-La

Answer 3

Sjogren’s syndrome, SLE

Question 4

Serum ACE

Answer 4

Sarcoidosis

Question 5

Anti-centromere antibody

Answer 5

Limited scleroderma

Question 6

Anti Jo-1

Answer 6

Polymyositis with lung involvement (may be dermatomyositis)

Question 7

Negatively birefringent crystals under polarised light (needle-like)

Answer 7

Gout

Question 8

Anti-cardiolipin

Answer 8

SLE + APLS

Question 9

Heliotropic rash and Gottron’s papules

Answer 9

Dermatomyositis

Question 10

Headache, raised ESR, trouble getting out of chair

Answer 10

GCA with polymyalgia rheumatica

Question 11

Anti-Smith

Answer 11

SLE

Question 12

Global loss of joint motion with stiffness

Answer 12

Adhesive capsulitis

Question 13

Anti-SCL-70 (anti topoisomerase)

Answer 13

Systemic sclerosis

Question 14

Polyarthritis, conjunctivitis, urethritis

Answer 14

Reactive arthritis (can’t see, can’t pee, can’t climb a tree)

Question 15

Positively birefringent crystals under polarised light

Answer 15

Pseudogout

Question 16

IgA with purpuic rash

Answer 16

Henoch-Schonlein purpura

Question 17

Anti-GBM

Answer 17

Goodpastures

Question 18

Shawl’s sign

Answer 18

Dermatomyositis

Question 19

Tensilon test

Answer 19

Myasthenia gravis

Question 20

Wrist pain on forced thumb adduction and flexion

Answer 20

De Quervain’s tenosynovitis

Question 21

Prominent and tender tibial tubercle

Answer 21

Osgood-Schlatter’s disease

Question 22

Hypopigmentation + autoimmune disease

Answer 22

Vitiligo

Question 23

Arthalgia + uveitis + orogenital ulcers

Answer 23

Behcet’s disease

Question 24

Positive Schirmer’s

Answer 24

Sjogren’s syndrome

Question 25

Question mark posture

Answer 25

Ankylosing spondylitis

Question 26

Arthralgia + reduced lung volumes

Answer 26

SLE

Question 27

Obese boy - hip flexed, abducted and externally rotated

Answer 27

Slipped femoral epiphysis

Question 28

Round-shouldered

Answer 28

Scheuermann's disease

Question 29

Gold standard for diagnosing Sjogren's

Answer 29

Salivary gland biopsy (lymphocytic infiltrate)

Question 30

Investigations for pathological fracture (2)

Answer 30

1. DEXA (OA) | 2. CMP/Bence-Jones (myeloma)

Question 31

Pencil in cup

Answer 31

Psoriasis

Question 32

RA + splenomegaly

Answer 32

Felty's syndrome

Question 33

Contortionist

Answer 33

Ehlers-Danlos syndrome

Question 34

Back pain + TB

Answer 34

Pott's disease of the spine

Question 35

Increased trabecular pattern and cortical thinking of the right hemipelvis with loss of joint space and osteophyte formation of the right hip

Answer 35

Paget's disease of bone

Question 36

PAS positive macrophages in intestinal biopsies

Answer 36

Whipple's disease

Question 37

Absent callus

Answer 37

Delayed union

Question 38

Painful shoulder after seizure

Answer 38

Posterior dislocation

Question 39

Gait seen in proximal myopathy

Answer 39

Waddling gait

Question 40

Twisting injury

Answer 40

Meniscal tear

Question 41

DRUG SE: irreversible retinopathy and alopecia

Answer 41

Hydroxychloroquine

Question 42

DRUG SE: gum hypertrophy

Answer 42

Ciclosporin Others: phenytoin, calcium channel blockers

Question 43

DRUG SE: exfoliative dermatitis

Answer 43

Gold

Question 44

DRUG SE: reversible oligospermia

Answer 44

Sulfasalazine

Question 45

DRUG SE: pulmonary and hepatic fibrosis

Answer 45

Methotrexate

Question 46

DRUG SE: nephrotic syndrome

Answer 46

Gold

Question 47

Cancer associated with Paget's disease of bone

Answer 47

Osteosarcoma

Question 48

Posterior fat pad sign

Answer 48

Radial head fracture

Question 49

Back pain + anterior uveitis

Answer 49

Ank spond

Question 50

DRUG: scleroderma crisis

Answer 50

ACE inhibitor