MT-Eicosanoids Flashcards Preview

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Flashcards in MT-Eicosanoids Deck (31):
1

COX-1 and COX-2 inhibit

cyclooxygenase

2

NSAIDs inhibit

cyclooxgenase

3

cell membrane to Arachidonic acid

phospholipases

4

phospholipases are inhibited by

corticosteroids

5

Arachidonic acid to 5-HPETE

5-Lipoxygenase

6

12-lipoxygenase

5-HPETE to Lipoxin A4 / Lipoxin B4

7

Lipoxins

vasodilation stimulate monocyte adhesioninhibit neutrophil chemotaxis

8

cellular component of inhibition of Lipoxins

inhibiting neutrophil chemotaxis

9

leukotrienes C4, D4, E4

vasoconstrictionBronchospasmIncreased permeability

10

leukotrienes do what to contribute to vascular component of inflammation

increase permeability of BVs

11

prostacyclin PGI2 causes

Vasodilationinhibits platelet aggregation

12

Thromboxane A2 causes

Vasoconstrictionpromotes platelet aggregation

13

______ and _____ are antagonistic

prostacyclin PGI2, Thromboxane A2

14

PGD2, PGE2, PGF2

vascular components of inflammationvia promoting vasodilation and edema

15

PGD2 is secreted by _____ and the _____

mast cells, brain

16

involved in type 1 hypersensitivity and asthma, also inhibits hair growth

PGD2

17

functions of PGE2

hyperalgesia, fever, uterine contraction, relaxation of cervix for labor

18

stope production of progesterone and induces labor

PGF2a (corpus luteum)

19

____ are arachadionic acid metabolites

eicosanoids

20

major producers of eicosandoids are _____ and _____

neutrophils, macrophages

21

Cox-1 inhibitors

NSAIDS

22

regulate amount of fluid and salt in kidneysprotect GI tract from ulceration and irritation

Cox-1 functions

23

what happens if COX-1 is inhibited for long periods of time

stomach ulterations/irritation (increase in HCL)kidney problems

24

only used when inflammation is necessary

COX-2

25

Inhibitors of COX-2 only

Vioxx, celebrex, meloxicam

26

Vioxx is not used because it can result in

MI, thombosis, throboaneurysm

27

Tumor necrosis factor (TNF) is produced by ______

activated macrophages

28

TNF induces

acute inflammatory response

29

TNF is inhibited by medication for

RA, akylosing spondylitis (shots are very effective)

30

TNF inhibition may lead to______

lymphomas

31

IL-1, IL-6 produced by helper T-cells and induce an acute ________ response

inflammatory