MT-Eicosanoids

Question 1

COX-1 and COX-2 inhibit

Answer 1

cyclooxygenase

Question 2

NSAIDs inhibit

Answer 2

cyclooxgenase

Question 3

cell membrane to Arachidonic acid

Answer 3

phospholipases

Question 4

phospholipases are inhibited by

Answer 4

corticosteroids

Question 5

Arachidonic acid to 5-HPETE

Answer 5

5-Lipoxygenase

Question 6

12-lipoxygenase

Answer 6

5-HPETE to Lipoxin A4 / Lipoxin B4

Question 7

Lipoxins

Answer 7

vasodilation stimulate monocyte adhesioninhibit neutrophil chemotaxis

Question 8

cellular component of inhibition of Lipoxins

Answer 8

inhibiting neutrophil chemotaxis

Question 9

leukotrienes C4, D4, E4

Answer 9

vasoconstrictionBronchospasmIncreased permeability

Question 10

leukotrienes do what to contribute to vascular component of inflammation

Answer 10

increase permeability of BVs

Question 11

prostacyclin PGI2 causes

Answer 11

Vasodilationinhibits platelet aggregation

Question 12

Thromboxane A2 causes

Answer 12

Vasoconstrictionpromotes platelet aggregation

Question 13

______ and _____ are antagonistic

Answer 13

prostacyclin PGI2, Thromboxane A2

Question 14

PGD2, PGE2, PGF2

Answer 14

vascular components of inflammationvia promoting vasodilation and edema

Question 15

PGD2 is secreted by _____ and the _____

Answer 15

mast cells, brain

Question 16

involved in type 1 hypersensitivity and asthma, also inhibits hair growth

Answer 16

PGD2

Question 17

functions of PGE2

Answer 17

hyperalgesia, fever, uterine contraction, relaxation of cervix for labor

Question 18

stope production of progesterone and induces labor

Answer 18

PGF2a (corpus luteum)

Question 19

____ are arachadionic acid metabolites

Answer 19

eicosanoids

Question 20

major producers of eicosandoids are _____ and _____

Answer 20

neutrophils, macrophages

Question 21

Cox-1 inhibitors

Answer 21

NSAIDS

Question 22

regulate amount of fluid and salt in kidneysprotect GI tract from ulceration and irritation

Answer 22

Cox-1 functions

Question 23

what happens if COX-1 is inhibited for long periods of time

Answer 23

stomach ulterations/irritation (increase in HCL)kidney problems

Question 24

only used when inflammation is necessary

Answer 24

COX-2

Question 25

Inhibitors of COX-2 only

Answer 25

Vioxx, celebrex, meloxicam

Question 26

Vioxx is not used because it can result in

Answer 26

MI, thombosis, throboaneurysm

Question 27

Tumor necrosis factor (TNF) is produced by ______

Answer 27

activated macrophages

Question 28

TNF induces

Answer 28

acute inflammatory response

Question 29

TNF is inhibited by medication for

Answer 29

RA, akylosing spondylitis (shots are very effective)

Question 30

TNF inhibition may lead to______

Answer 30

lymphomas

Question 31

IL-1, IL-6 produced by helper T-cells and induce an acute ________ response

Answer 31

inflammatory