Musculoskeletal System- MoA

Question 1

Methotrexate

Answer 1

Inhibition of dihydrofolate reductase and DNA synthesis for lymphocyte proliferation

Question 2

Thiopurine antiproliferative

Answer 2

Inhibitor of purine synthesis – possible inhibition of DNA synthesis and lymphocyte proliferation

Question 3

Cytokine modulators

Answer 3

TNF-alpha blockade

Question 4

Aminosalicylates

Answer 4

Possible COX inhibition. Free radical scavenging, T cell suppression

Question 5

Leflunomide

Answer 5

Inhibitor of pyrimidine synthesis, reducing DNA & RNA synthesis and lymphocyte proliferation

Question 6

Colchicine

Answer 6

Possible inhibition of inflammatory cell motility

Question 7

Xanthine oxidase inhibitor

Answer 7

Inhibition of uric acid synthesis

Question 8

Indometacin

Answer 8

COX enzyme inhibition