Flashcards in ND - L1 Deck (18):
1
Classic view to study disease
make a model
explain pathogenesis
histology
biochemistry
phenotype
2
Disease elements
risk factors
disease onset
active disease
failed organ
3
Parkinson's progression of understanding
Parkinsonism
substantia nigra cell loss
Lewy bodies
dopamine
a-synuclein
a-synuclein primary component of Lewy bodies
4
Relate the disease elements to PD
? + genes
disturbance in a-syn causing LBs
loss of midbrain neurons, causing loss of dopamine transmission
motor symptoms of PD
5
What is the MND SOD1 observation about?
-
6
Why do clinical signs matter?
beginning of understanding process:
7
Clinical signs of late PD
sleep disorder
autonomic failure
motor signs
dementia
impulsivity
neuro-psychiatry
8
What are the main elements of PD pathology?
substantia nigra cell loss
Lewy bodies
a-syn
9
What is the SNs location & function? What are its two parts?
midbrain, forms part of basal ganglia
controls voluntary movement, produces dopamine
pars compacta (pigmented), pars reticulata (unpigmented)
10
Where does the SN connect to?
striatum
11
What does the striatum do?
panning & modulting movement
12
Describe a-syn
-
13
Describe a-syn pathway
-
14
What can modulate the aggregation of a-syn?
genetics
dopamine (how?)..
iron, oxidants, environmental toxins can increase aggregation
15
What are the two theories for the spread of a-syn?
-
16
Key points
The single etiology model doesn’t work
Risk and end stage are different entities
What constitutes “X disease” is constantly changing
Clinical Signs tell you the anatomical pathology
Similar cells have similar diseases susceptibility
Each Neurodegeneration affects a system of cells
Neurodegenerations Progress- WHY?
How should we classify neurodegenerations?
17
Common features of late onset neurodegenerations
post fertile genes
common mechanisms (spreading, energetics, axon transport problems, inclusion formations)
18