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Flashcards in RA - L4 Deck (6)
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1

Patterns of Bone Loss in RA

juxta-articular osteopenia
focal bone erosion
systemic osteoporosis

2

Where does RANKL come from?

osteoblasts
synovial fibroblasts (additional source)
T cells (additional source)

3

What are the cells responsible for bone erosion in RA?

osteoclasts ONLY

4

What is OPG.Fc treatment?

increase in OPG expression
decreased bone erosion

5

What cytokines promotes osteoclast differentiation directly?

RANKL
IL-1
TNF

6

What cytokines promotes osteoclast differentiation indirectly?

TNF
IL-6
IL-1
IL-17