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Flashcards in RA - L5 Deck (6)
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1

Phases of clinical trials?

Phase I: small group to evaluate safety
Phase II: efficacy, through large group
Phase III: compare to gold standard
Phase IV: post marketing surveillance

2

What are the types of medications used in RA treatments?

Analgesics
NSAIDS
Glucocorticoids
DMARDs (actually modify course of disease)
bDMARDs

3

Classes of bMARDs?

TNF a inhibitors
IL-1 antagonists
IL-6 receptor antagonists
CTLA4 ligand
B cell depleting agents

4

PBS criteria for bMARD eligibility?

failed 6 months of intensive DMARDs
ESR>25mm/h, CRP>15mg/L
active joint count: >20 active, >4 major

5

Treatment Principles of RA

treat early
treat-to-target
intensive therapeutic regimens
combination of DMARDs
escalating and frequent changes

6

Evidence for intensive regimens

TICORA
less radiographic joint erosions
no increase in adverse events
cost saving (short term)
BeSt Study