Flashcards in RA - L5 Deck (6)
Phases of clinical trials?
Phase I: small group to evaluate safety
Phase II: efficacy, through large group
Phase III: compare to gold standard
Phase IV: post marketing surveillance
What are the types of medications used in RA treatments?
DMARDs (actually modify course of disease)
Classes of bMARDs?
TNF a inhibitors
IL-6 receptor antagonists
B cell depleting agents
PBS criteria for bMARD eligibility?
failed 6 months of intensive DMARDs
active joint count: >20 active, >4 major
Treatment Principles of RA
intensive therapeutic regimens
combination of DMARDs
escalating and frequent changes