Nematode and cestode infections in sheep Flashcards

(57 cards)

1
Q

What are the roles of vets when there are nematode/cestode infections in sheep?

A
  • Devising worm control strategies (Flock Health Plans)
  • Advising on outbreak parasitic disease occurs
  • Advising on poor growth in lambs/ thin ewes
  • Advising when anthelmintic resistance problems occur
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2
Q

What are the 3 main current problems with parasite control in sheep?

A
  • Drug resistance
  • Climate change
  • Parasites
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3
Q

Describe how drug resistance is becoming a major problem with parasite control in sheep

A
  • Maintaining high levels of production relies on heavily stocked pasture and intensive anthelmintic use
  • Inappropriate use of anthelmintics
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4
Q

Describe how climate change is becoming a major problem with parasite control in sheep

A

Mild winters warmer spring summer increased new species and increased parasite numbers on pasture

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5
Q

How is anthelmintic resistance defined?

A

Defined as drug <95% efficacy

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6
Q

What can be done about anthelmintic resistance?

A
  • Devise sustainable parasite control plans
  • Reduce selection pressure to slow progression of resistance
  • Improve biosecurity to prevent introduction of resistant strains
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7
Q

How do nematode infections cause clinical disease in sheep?

A
  • Damage lining of guts (reducing absorption)
  • Remove nutrients
  • Remove blood (Haemonchus)
  • Host immune response (host resources and damage)
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8
Q

What are the overall clinical signs of nematode infections in sheep?

A

Reduced appetite. Poor weight gain/ weight loss
Submandibular oedema
Diarrhoea
Anaemia
Death

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9
Q

Outbreaks of acute severe diarrhoea and death lambs 6-12 weeks old are caused by which nematode infection?

A

Nematodirus battus

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10
Q

Describe type I and II Teladorsagia infections

A

Type 1: Lambs first grazing season, mid summer onwards
Type 2: yearlings winter months, emergence of hypobiotic larvae

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11
Q

Lambs with black scour occurring the the late summer/autumn months is caused by which nematode?

A

Trichostrongylus

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12
Q

What are the signs of Haemonchus contortus infections?

A

Adults and lambs
Acute regenerative anaemia
Chronic hypoproteinaemia, anaemia bottle jaw
Sudden death

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13
Q

How long does is take for the egg to develop into L3 in:
1. early spring
2. early summer

A

1 = 10-12 weeks
2 = 1-2 weeks

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14
Q

Development L3 to eggs in sheep takes how long?

A

16-21 days

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15
Q

Which nematode spp numbers peak in early summer?

A

Teladorsagia

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16
Q

Which nematode spp numbers peak in late summer/autumn?

A

Trichostrongylus

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17
Q

Describe hypobiosis

A

L3 late autumn early winter over winter period interrupted development L4 stage inside sheep

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18
Q

What is the consequence of hypobiosis?

A

Pasture contamination in spring and early summer

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19
Q

Describe the epidemiology of N.battus

A
  • Eggs shed by lambs one year, remain on pasture and infect next year lambs
  • Mass hatching of L3
  • Severe outbreaks of diarrhoea in 6-12 week old lambs
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20
Q

When does hatching/release of N.battus eggs occur?

A

Prolonged period of chill followed temperature range of 10C-18C leads to large numbers of L3 hatching simultaneously

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21
Q

Describe sheep immunity to nematodes

A

Providing they have been exposed to nematodes LAMBS should be developing resistance to nematodes around 5-6 mo

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22
Q

Immunity to nematodes is influenced by which factors?

A

Nutrition (protein)
Genetics (opportunity breeding)
Stage of production

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23
Q

What does SCOPS stand for?

A

Sustainable control of parasites in sheep

24
Q

Which anthelmintics are described as ‘white drench’?

A

Benzimidazoles

25
What is the function of benzimidazoles?
Tubulin binding, prevents uptake of glucose, ovicidal (kills eggs)
26
Describe use/resistance to benzimidazoles
- Broad spectrum - N.battus resistance reported - More resistance so may not work
27
Which anthelmintics are described as 'yellow drench'?
Levamisole - imidazothiazines
28
What is the function of levimisole?
Ganglion blocking drugs, paralysis not ovicidal
29
Which anthelmintics are described as 'clear drench'?
Macrocytic lactones
30
What is the action of macrocytic lactones?
Block Cl- and GABA channels -> paralysis
31
All injectable forms of which anthelmintic are active against mange mites (sheep scab)
Moxidectin (MLs)
32
Which group of anthelmintics are known as 'orange drenches'?
Amino-acetonitrile
33
Which group of anthelmintics are known as 'purple drenches'?
Spiroindoles
34
How should group 4 and 5 (new generation) antibiotics be used?
Do not keep for best, should be used regularly as part of drug rotation in worm control plan, especially useful at quarantine dose
35
Key factors influencing the development of Anthelmintic Resistance in a population are?
- Treatment frequency - Under dosing - Biosecurity: new strains introduced - Proportion of population exposed to treatment “in refugia”
36
How can you detect that resistance is present?
Clinical signs: - Lamb growth rates reduced - EID regular weighing DLWG really useful - Diarrhoea - Death
37
Which test can be used to know if resistance is present?
Faecal Egg Count Reduction Test - should be reduced to zero after administration of drug. If reduction is 95% or less, resistance has been detected.
38
Describe how to carry out the faecal egg count reduction test
* 10 lambs per group - Weigh and mark * Pre-treatment FEC * Accurate dose drug * 7-14 days post treatment (depending on drug used) FEC
39
Describe the drench test
(cheaper quicker less accurate) post treatment FEC check * FEC 7-14 days post treatment (depending on drug) * Pooled worm egg count
40
What are the 4 SCOPS principles?
1. Always make sure treatment is fully effective 2. Reduce dependence on anthelmintics using management and monitoring 3. Avoid bringing in resistant worms and/or other parasites by following a robust quarantine routine. Test for anthelmintic resistance 4. Minimise the selection for worms that are resistant to anthelmintics when you treat sheep.
41
How can you avoid under-dosing?
- Pick the heaviest sheep in group, weigh it - If big range in sizes then sub group - Check dosing gun - Test for resistance - Make sure you are using the correct product for the task
42
Adult sheep should have immunity to all but which nematode?
Haemonchus contortus
43
Why are adult sheep treated?
To reduce pasture contamination for lambs
44
Which adult sheep should be treated?
only treat thin sheep, triplet bearing ewes, shearlings ewe lambs, ie not fit singles, twin bearing ewes - not routine to dose everything
45
When are adult sheep treated for nematode infections?
At tupping time
46
Barbervax is used for?
Haemonchus
47
How can management of growing lambs be used to reduce anthelmintic use?
- Rotational grazing - Leave ewes on high risk pastures - Good nutrition - Manage concurrent disease - Genetic selection - Vaccination program
48
Why cant faecal egg counts be used to target treatment for N.battus?
Larval stages causing disease can cause false negatives
49
How is forecasting used for N.battus
Temperature conditions across the country indicate when the risk is Preventative dosing with BZ wormer (white drench)
50
How are brought in sheep managed to avoid bringing in resistant worms?
Dose with monopantel Hold off pasture 24-48 hours allow treatment to work Return to contaminated pasture
51
When will lambs not need to be wormed?
If they are growing at their required growth rates
52
What is the FAMANCHA test for Haemochus?
Use pallor of eye mucous membranes. Pale = dose!
53
What are the other clinical signs of Haemonchus infections?
Weakness, Collapse, Hyperpneoa, Tachycardia, Sudden death
54
Describe 'in refugia'
If we dose the sheep with anthelmintic when the majority of worm population is in the sheep, ie when free living population is lowest rapidly select for resistance.
55
When are the 'in refugia' times of the year?
Autumn Winter Early spring
56
What are the effects of cestode infections in sheep?
Carcass condemnation Echinococcus granulosus is zoonotic Gid cysts in the brain
57
The sheep is the final host of which tapeworm infection?
Monezia expansa