Neurological Disease In Sheep Flashcards

(49 cards)

1
Q

What questions should be asked when gathering the history for a neurological case?

A
  • Age group
  • Number affected
  • Speed of onset
  • Speed of progression
  • Time of year
  • Feeding
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2
Q

Once the history has been gathered what are the next steps in a neurological case?

A

Full clinical exam
Neurological exam

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3
Q

If the cerebrum is affected the stage of disease correlates with?

A

The severity of the signs

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4
Q

What are some signs you would see which would correlate with a diffuse cerebral lesion?

A
  • Altered mental state i.e. depressed, disorientated, hyperexcitable
  • Blindness
  • Seizures
  • Opisthotonus
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5
Q

What is Opisthotonus?

A

D dramatic abnormal posture due to spastic contraction of the extensor muscles of the neck, trunk, and lower extremities that produces a severe backward arching from neck to heel
* Recumbant
* Extended front legs flexed hind legs

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6
Q

Name 3 example causes of a diffuse cerebral lesion

A
  • Bacterial meningitis
  • Cerebrocortical necrosis
  • Pregnancy toxaemia
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7
Q

What signs would you see that would correlate with a local cerebral lesion?

A
  • Contralateral blindness
  • Circling
  • Proprioceptive deficits
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8
Q

Name 3 example causes of a localised cerebral lesion

A
  • GID cysts (coenuris cerebralis, Taenia multiceps)
  • Brain abscess
  • Trauma
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9
Q

What signs would you see that would correlate with a cerebellar lesion?

A
  • Altered head carriage
  • Balance: ataxic, but not weak
  • Wide stance
  • Dysmetria
  • Intention tremor including nystagmus
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10
Q

What is a congenital cause of a cerebellar lesion?

A

Cerebellar hypoplasia

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11
Q

What is an infectious case of cerebellar lesions?

A

Border disease
- Cerebellar hypoplasia

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12
Q

What signs would you see that would correlate with a lesion of the vestibular system?

A
  • Head tilt towards the affected side
  • Loss of balance
  • Circling
  • Falling/rolling to one side
  • Spontaneous nystagmus
  • Middle ear infection
  • Unilateral facial nerve paralysis
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13
Q

Which condition leads to lesions in the brainstem?

A

Listeriosis

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14
Q

What signs would you see that would correlate with a brainstem lesion?

A
  • Depression
  • Multiple cranial nerve deficits
  • Ipsilateral hemiparesis
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15
Q

What signs would you see that would correlate with a spinal lesion?

A
  • No signs of central disease
  • Depends on site of spinal cord
  • Tetraparesis/ paraparesis
  • Proprioception
  • Skin sensation
  • Pain
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16
Q

What are some possible causes of spinal lesions?

A
  • Trauma
  • Congenital abnormality
  • Spinal abscess e.g. joint ill tick pyaemia
  • Wobblers syndrome in Texel’s
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17
Q

List some possible causes of neurological diseases that could affect lambs from 0-3months old (9 possible)

A
  • Border disease
  • Congenital swayback (copper deficiency)
  • Drunken lamb disease
  • Bacterial meningitis
  • Spinal abscess
  • Listeriosis
  • Louping ill
  • Tetanus
  • Trauma
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18
Q

How would a lamb with bacterial meningitis present?

A

Collapsed

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19
Q

If a lamb was circling with facial paralysis which disease would be indicated?

A

Listeriosis

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20
Q

Which neurological disease of young lambs is tick borne?

21
Q

What are the clinical signs of louping ill?

A
  • Head pressing
  • Trembling & tremors
  • Nystagmus
  • Lip twitching etc
  • “louping gait”
22
Q

List some possible causes of neurological diseases that could affect lambs from 3+ months

A
  • Cerebrocortical necrosis
  • Listeriosis
  • GID
  • Louping ill
  • Trauma
23
Q

What is the cause of cerebro-cortical necrosis?

A

Vitamin B1 (thiamine) deficiency

24
Q

What is a likely history for an animal with cerebro-cortical necrosis?

A

Diet change or worming
Thiaminase production in rumen

25
What are the clinical signs of cerebro-cortical necrosis?
* Dull * Disorientated * Blind * Tremors * Recumbency * Opisthotonus * Convulsions
26
How can cortico-cerebral necrosis be treated?
* Vitamin B1 iv (slow 10mg/kg) * Vit B1 i/m every 12 hours For 3 days * House quietly * Vision should return 5- 7 days
27
Name the agent that cause listeriosis
Listeria monocytogenes
28
Listeriosis is associated with what kind of feeding?
Feeding poorly preserved silage soil that has gone mouldy
29
What is the pathway in the body of a listeria infection?
An ascending infection to the brainstem
30
What are the clinical signs of listeriosis?
- Anorexia, depression - Unilateral hemiparesis - Trigeminal nerve paralysis - Facial nerve paralysis
31
What signs are seen with trigeminal nerve paralysis caused by listeriosis?
Salivation Food impaction in the cheek
32
What signs are seen with facial nerve paralysis caused by listeriosis?
Drooped ear Drooped lower eyelid Deviated muzzle Loss of blink
33
How would you diagnose listeriosis?
* Clinical signs * CSF tap * PM
34
How can you treat listeriosis?
- Good prognosis if caught early - Remove silage - Benzylpenicillin IV - Procaine penicillin IM - Dexamethozone IV
35
What is the cause of gid?
Taenia multiceps
36
Describe the pathogenesis of taenia multiceps
* Eggs picked up by sheep, cysts develop in brain cerebral, cerebellar (Coenoris cerebralis) * Primary host dog
37
What are the clinical signs of taenia multiceps infection?
Gradual onset Circling Unilateral blindness (opposite to lesion) Head tilt Skull softening
38
What is the treatment and prognosis of taenia multiceps?
* Surgical * Signs depend on site of lesion * Cerebral – good prognosis * Cerebellar – poor
39
How can flocks be controlled to manage Taenia multiceps?
* Worm dogs every 6 weeks praziquantel * Keep away from sheep carcasses
40
Vestibular disease is commonly misdiagnosed as?
Listeriosis
41
What are the clinical signs of vestibular disease?
- Loss of balance - Head tilt towards the affected side - Horizontal nystagmus - Aural discharge - Facial nerve paralysis
42
How is vestibular disease treated?
5 days of penicillin
43
List some possible causes of neurological diseases that could affect adult sheep
- Gid cyst - Listeriosis - Brain abscess - Louping ill - Trauma - Metabolic disease
44
Compare the neurological clinical signs in the following 3 metabolic diseases in adult pregnant sheep 1. Pregnancy toxaemia 2. Hypocalcaemia 3. Hypomagnesemia
1. Dull, blind 2. Collapsed, bloated, flaccid paralysis 3. Staggers, hyperaesthesia
45
Define classical scrapie
- Infectious neurological disease of sheep - Fatal chronic progressive, brain disease of sheep
46
Describe the aetiology of scrapie
- Causes abnormal protein to accumulate especially in brain causing neurological dysfunction - Spread mother to offspring (vertical transmission) prenatally and colostrum and milk - Horizontally birth fluids, placenta - Considerable Genetic Variation in Susceptibility to Infection
47
What are the clinical signs of scrapie?
- Progressive Fatal Neurological disease - Long incubation period: 2-5 years old - Single animal - Altered mental state excitable nervous depressed, aggressive - Trembling - High step ataxia - Recumbency - Skin prurititus, rubbing scratching, wool loss - Weight loss - Death
48
What should you do if scrapie is suspected?
Notifiable Report to AHVLA Test animal - If positive - Compulsory Scrapie Flocks Scheme - Movement Restriction, Genotyping, Testing and Culling
49
How is pregnancy toxaemia diagnosed and treated?
Diagnosis –BOHB levels blood Treatment – poor prognosis unless early