Neoplasia 2: Signal Transduction (Oncogenic Activation)

Question 1

GTP-binding (G) Proteins (2)

Answer 1

KRAS (pt. mutation): Colon, lung, and pancreatic tumors

NRAS (pt. mutation): melanomas, hematologic malignancies

Question 2

Non-receptor TRK - *ABL

Answer 2

If Translocation: CML (9,22)
If Pt. mutation: AcuteLL

*If ABL fuses with BCR to form the ABL-BCR gene, it now GAINS TYROSINE KINASE ACTIVITY –> Philadelphia chromosome. 9 and 2, CML

Question 3

Non-receptor TRK: JAK/STAT Signal transduction - JAK2

Answer 3

Translocation: Myeloproliferative disorders, and AcuteLL

Increased RBC, HCT, and polycythemia vera