Neoplasia 3: Paraneoplastic Syndromes Flashcards
Paraneoplastic Syndromes
Tumor secretes excess of SOME substance that goes and affects another organ
Endocrinopathies: Cushing Syndrome
Substance: ACTH or ACTH-like substance
Small-cell carcinoma of lung
Pancreatic carcinoma
Neural tumors
Endocrinopathies: SIADH
Substance: ADH or ANP
Small-cell carcinoma of lung Intracranial neoplasms (Rathke's pouch, diabetes insipidus)
Endocrinopathies: Hypercalcemia (4)
Substance: PTH-related protein (PTHRP), TGF-alpha, TNF, or IL-1
Squamous cell carcinoma of lung
Breast carcinoma
Renal carcinoma
Adult T-cell leukemia/lymphoma
Endocrinopathies: Polycythemia (3)
Substance: Erythropoietin
Renal carcinoma
Cerebellar hemiangioblastoma
Hepatocellular carcinoma
Nerve and Muscle Syndromes: Myasthenia
Immunologic
Bronchogenic carcinoma
Thymic neoplasma
Nerve and Muscle Syndromes: Disorders of CNS and PNS
Breast carcinoma
Dermatologic Disorders: Acanthosis Nigricans
Immunologic: secretion of EGF
Gastric carcinoma
Lung carcinoma
Uterine carcinoma
Dermatologic Disorders: Dermatomyositis
Immunologic
Bronchogenic carcinoma
Breast carcinoma
Hypertrophic osteoarthropathy and clubbing of fingers
Bronchogenic carcinoma
Venous Thrombosis (Trousseau phenomenon)
Substance: Tumor products (mucins that activate clotting)
Pancreatic carcinoma
Disseminated Intravascular Coagulation (DIC)
Affects multiple organs, widespread
Substance: tumor products that activate clotting
Acute Promyelocytic Leukemia (15,17, RAR-alpha)
Prostatic carcinoma
Red Cell Aplasia
Substance: Unknown
Thymic neoplasms (secrete autoantibodies against own RBC PRECURSORS only)
Nephrotic Syndrome
Tumor antigens, immune complexes
Various cancers
