Neoplasia 3: Grading and Staging of Tumors

Question 1

Low grade (1-2)

Answer 1

Well-differentiated, resembles almost normal cells, but will have features of malignancy

Question 2

High grade (3-4)

Answer 2

Poorly or moderately differentiated: won’t be resembling origin or tumor, but will be a high grade tumor. Invasive, metastatic, and aggressive.

Question 3

Staging:

Answer 3

Based on clinical, radiological, and surgical criteria: tumor size, involvement of regiolin LNs, and presence of metastases

E.g. Gleason’s grading: only based on microscopic features of prostatic adenocarcinoma