Neoplasia 3: Radiation Carcinogenesis

Question 1

UV Radiation

Answer 1

MOA: Pyrimidine dimers –> DNA damage giving rise to xeroderma pigmentosa, which can then lead to skin cancers

Skin cancers: Basal cell carcinoma, squamous cell carcinoma, and melanomas

Question 2

Ionizing Radiation

Answer 2

Direct and indirect (Via free radicals)

High linear energy transfer (LET) as in particulate radiation (neutrons and alpha rays) than with low LET or electromagnetic radiation (X-rays and gamma rays)

Question 3

Radiation-Induced Neoplasma

Answer 3

Atomic Bomb survivors prone to:
Thyroid papillary cancers
Leukemias EXCEPT CLL