Neoplasia II Flashcards Preview

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Flashcards in Neoplasia II Deck (33):
1

limitless replicative potentail

neoplasms

2

limited replicative potential

normal tissue

3

loss of contact inhibition

neoplasm

4

neoplastic cells remain in the ...

cell cycle

higher percentage of cells in the cell cycle correlates with malignancy

5

clincally detectable mass

30 doublings- I g

6

max compatible with life

30 + 10 more doublings- 1 kg

7

when is a tumor growth fraction highest

during earlier stages

it is growing rapidly at this time

8

indicators of proliferation

ki-67

PCNA

9

PCNA

marker for cell proliferation

10

ki-67

marker for cell proliferation

11

how do you figure mitotic activity

county number of mitotic figures at 10 high powre

12

fragmentation of the nuclear chromatin

apoptotic body

13

condensation of the nucelar chromatin

apoptotoic body

14

what is the clinical significance of difference in growth rate of tumors?

cells within the cell cycle are susceptible to chemo and radiotherapy

15

highly susceptible to chemotherapy

cancers with rapid growth

16

benign tumor differentiation

always differentiated

17

malignant tumor differentiation

less differntiation

because within cell cycle

18

complete lack of differentiation

anaplasia

hallmark of high grade malignant tumor

19

resembles normal thyroid but forms an encapsulated thyroid mass

thyroid adeoma

20

may resemble normal thyroid tissue but shosw invasion

thyroid carcinoma well-diff.

21

poor resemblance to normal thyroid, few follicles scant colloid has metastatic potential

poorly idfferentiated carcinoma of thyroid

22

no resemblance to normal thyroid tissue high metastatic potential

anaplastic carcinoma of thyroid

23

where is cellular atypia seen?

only in pre-malignant and malignant tumors

24

key features of cellular atypia

- cells and their nuclei vary in size and shape
- dense and irregular nuclear outline
- nucelar hyperchromicity
- 1:1 nucelus/cytoplasm ratio

25

abundant dna, extremel dark staining

hyperchromasia

26

variation in size and shape of cells and nuclei

pleomorphism

27

tumor giant cells represent

anaplasia

nuceli are hyperchromatic and large

28

more anormal the mitoses, the more

likely the neoplasm is malignant

29

hyperplasia of activated fibroblasts

desmomplasia

30

imporant factors in tumor angiogenesis

VEGF
FGF

31

pro-angiogenic factors

VEGF
bFGF
HIF

32

anti-angiogenic factors

thrombospondin-1
angiostatin
endostatin
turnstatin

33

why do malignant tumors show central necrosis?

tumor outgrows its blood supply and areas of ischemic necrosis appear