Neoplasia VI Flashcards Preview

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Flashcards in Neoplasia VI Deck (48):
1

uv radiation via pyrimidine dimers --> DNA damage and NER pathway

skin cancer

those with enzyme defects in NER pathway are highly susceptible (xeroderma pigmentosum)

2

ionizing radiation

chromosome breakage, translocation and pt mutation

3

atomic bomb

leukemia (except CLL)

thyroid cancer

4

x ray workers

radiatin dermatitis and skin canceres

5

dials of watches with radium

osteosarcoma

6

hepatitis B virus --> hepatocellular carcinoma

chronic liver cell injury arnd regenrative hyperplasia

also HBx prtn with activates growth promoting genes and binds p53

7

hepatitis C virus --> hepatocellular carcinoma

chronic liver cell injury and regeneration

8

burkitt lymphoma
hodgkin lymphoma
Bcell lymphoma in immunosuppressed
nasopharyngeal carcinoma

EBV

9

high risk HPV

16,18,31 viral dna integrates into host genome

10

E6 HPV gene

inhibits p53

11

E7 HPV gene

inhibits Rb

12

HTLV-1 human t cell leukemia virus type 1

Cd4 tropism

Tax gnes which activates cFos IL2 GM-CSF and inactivates p16INK4a

stimualtes trx of viral mRNA

13

HIV -->

lymphoma

14

HHV8

kaposi sarcoma

15

helicobater pylori

gastric MALT lymphomas and gastric carcinoma

via CagA gnee stimulating growth factor pathway

16

estrogen hormonal carcinogenesis

breat cnacer

quamous cell carcinoma of cervic

leiomyoma of uterus

17

contraceptive hormones

breast cnacer

beinign/malignant liver tumors

18

anabolic steroids

benign/malignant liver tumors

19

loss of body fat wasteing and profound weakness

cancer cachexia ------- associated with TNF

20

what are para-neoplastic syndromes

distant effects of a tumore unrealted to primary tumor or metastasis

21

lung cancer para neoplastic syndrom

ACTH cushing syndrom

diabetes, wt loss, hypertesnion

22

small cell carcinoma of lung para-neoplastic syndrome

hyponatremia.SIADH

asoociated with aDH

23

acnathosis nigricans

black armpit associated withstomach carcinoma (you may also see leser-trelat sign)

24

carcinoid syndrome (flushing, diarrhea, bronchospasm, tachycardia)

because tumor secretes serotonin (observe 5-HIAA in urine)

carcinoid tumor located on appendix or small intestine

25

malignancy acounts for __- cases of yeprcalcemia

40%

26

causes of hypercalcemia in malig nancy

release of PTH related peptide (squamous cell ca of lunga dn renal ca)

osteolytic bony metastasis (breast cancer)

27

observe hypocalcemia

calcitonin

medullary ca of thyroid

28

observe gynecomastia

B-HCG hormone

chroicCA testis

29

eaton-lambert syndrome

myasthenia gravis like syndrome

small cell CA of lung

30

what would you use when you do not know the cell of orign of tumor

immunohistology

31

cytokeratin or eptithelia membrane antigen

epithelial origin

32

vimentin or desmin

mesenchmal origin

desmin is muscle specifically

33

LCA leukocyte common antigen

leukocyte origin

34

NSE neruonal specific enolase

neuronal tumor or smal cel carcinoma of lung

35

chromogranin and synaptophysin

neuronal tumor

36

thryroglobulin

thyroid cnacer

37

CD10

acute lympho alstic leukemai

38

placental alkaline phosphatase

seminoma

39

vWF, CD31

vascualr neoplasma

40

CEA antigen

tumor marker for CA colon, pancrease, stomach and breat

41

PSA

prostate cancer marker

42

B human chorionic gonadotropin

trophoblastic tumore marker

43

CA125

ovarian carcinoma marker

44

alpha fetoprtn

hepatocellular carcinom and germ cell tumor of testes.ovary marker

45

NSE

marker for small cell carcinoma of lugn

46

calcitonin

marker for medullary thryodi carcinoma

47

CA 19-9

marker for colon cancer, pancreatic cancer

48

CA 15-3

marker from breast carcioma