Neoplasia V Flashcards Preview

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Flashcards in Neoplasia V Deck (23):
1

APC tumor suppressor gene

prevents nuclear transcription

famlial polyposis coli (adenocarcinoma of colon)

2

BRCA-1/2 tumor suppressor gene

regulates DNA repair

breast and ovarian cancer

3

RB gene tumor suppressor gene

inhibits GI to S phase

retinoblastoma and osteogenic sarcoma and soft tissue sarcoma

4

normal WNT pathway

APC prtn down regulaes B catenin and prevents its acumulation

5

inactivation of APC-->

increased levels of B catentin and continuous WNT signaling

FAP, non-familial clolorectal CA and sporadic adenomas

6

knudsons two hit hypothesis

(retinoblastoma)

both alleles of Rb locus must be inactivated

7

p53 tumor suppressor gene

inhibits G1 to S phase, repairs DAN, activates BAX

associated with lung, colon, breast CA and Li-Fraumeni syndrome

8

functions of p53 (2)

cell cycle arrest via p21

proapoptosis via BAX

9

VHL tumor suppressor gene

regulates nuclear trx via HIF-1a

hereditary renal cell carcinoma
pheochromocytoms
hemangioblastomas f CNS
retinal angiomas
renal cysts

10

warburg effect

tumor cells prefer glucse and aerobic glycolysis

this can be detected with a PET scan if tumor is rapidly growing

11

highly reactive electrophiles that remove electrons from DNA, RNA or rtns and cause cell damage

chemical carcinogens

12

steps of chemical carcinogenesis

first permanent initiation and reversible promotion that induces tumors

13

polycyclic aromatic hydrocarbons (smoke)

lung and bladder cancers

14

aromatic amines and azo dyes

liver cancer

15

B-naphtyhylamine (aniline dye)

bladder cancer

16

Aflatoxin B1

mycotoxin produced by fungus --> hepatocellular carcinoma via p53 mutations

17

nitrosamines and amines

associated with gastric carcinoma

18

asbestos

mesothelioma

19

chromium nickle

lung cancer

20

arsenic

skin cancer

21

estrogen as promoter of chemical carcinogenesis

liver tumors

22

diethyl-stilbesterol as promoter of chemical carcinogenesis

post-menopausal endometrial CA

vagianl cancer in offspring exposed in utero

23

high dietary fat and increased bile acids promote

colon CA