Neoplasia IV Flashcards Preview

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Flashcards in Neoplasia IV Deck (21):
1

CIA is applicable ..

only to epithelial neoplasms

2

oral leukoplakia via dysplasia

squamous cell carcinoma

3

barret esophagus via dysplasia

adenocarcinoma of esophagus

4

chronic atrophic gastritis of pernicious anema via dysplasia

gastric adenocarcinoma

5

chronic ulcerativ colitis via dysplasia

adenocarcinoma of colon

6

hepatitis infection B or C via macronodular cirrhosis

hepatocellular carcinoma

7

atypical hyperplasia of endometrium

endometrial adenocarcinoma

8

solar keratosis of skin

skin cancer (squaous cell carcinoma)

9

7 essential alterations for malignant transformation

1. self-sufficiency in growth signals
2. insensitivity to growth -inhibitory signals
3. evasion of apoptosis
4. limitless replicative potential
5. sustained angiogenesis
6. ability to invade and metastasize
7. defects in dna repair

10

ERB2/HER2/NEU growth factor receptor

amplification--> breast cancer and ovarian cancer

11

RET growth factor receptor ***

point mutation --> MEN multiple endocrine neoplasia 2A/B, familia medullary thyroid carcinomas or hyperplasia

12

KRAS signal transduction prtn

point mutation ---> pancreas, colon, lung cancers

13

ABL signal transduction prtn

translocation --> chronic myeloid leukemia and acute lymphoblastic leukemia

14

B-catenin signal transduction prtn

point mutation or overexpression ---> hepatoblastomas and hepatocellular carcinoma

15

C-myc nuclear regulatory prtn ***

translocation 8 to 14 causes excess trx signals---> burkitt lymphoma

16

N-myc nuclear regulator prtn

amplification --> neuroblastoma, small cell CA of lung

children

17

Cyclin D cell cycle regulator

translocation ---> mantle cell lymphoma

amplification --> breast and esophageal cancer

18

Chronic myelogenous leukemia

abl 9 translocated to bcr 22

leads to increased tyrosine kinase

"philadelphia chromosome"

19

what do you treat chronic myelongenous leukemia with?

imaitinib which inhibits tyr kinase

20

B cell follicular lymphoma

over expression of BCL2 via 14-18 translocation prevents apoptosis of B lymphocyte --> follicular lymphoma

"evasion of apoptosis"

21

pathogenesis exclusively by evasion of apoptosis

follicular lymphoma