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Flashcards in Neoplasia III Deck (52):
1

4 steps of invasion of ECM

1. detachment
2. attachment
3. degradation
4. migration

2

detachment of tumor cells from each other

E-cadherin not produced

3

attachment to matrix component

laminin and laminin receptor

4

degradation of ECM

collagenases (MMP) degrade type IV collagen

5

migration of tumor cells

- binding of fibronectin receopto
- motility factor secreted by tumor cell

6

expression of _____-- on tumor cells favors metastasis

CD44

7

malignant cells exfoliate and implant and invade tissue in a body cavity

seeding of body cavities

8

most common type of metastasis

lymphatic spread

9

is lymphatic spread more typical of carcinomas or sarcomas

carcinomas

10

painful nodule in lymph node

pain is a good thing

cancer is usually painless (non-tender)

11

follicular carcinomas

local invasion spread
(no lymph spread)

12

renal cell carcinoma

spread via renal vein to IVC
(no lymph spread)

13

hepatocellular carcinoma

hematogenous spread (no lymph spread)

14

spread typical of sarcomas

heamtogenous

15

rhabdomyosarcoma

local invasion
(not blood)

16

multiple mass lesions with central areas of umbiilcation

characteristic for metastases to liver and lung

17

first node in a regional lymphatic system that receives lymph flow from primary tumor

sentinel lymph node

18

most common site for bony metastasis

vertebral column

19

most common symptom of bone metatstasis

pain

20

osteoblastic v. osteolytic metastasis

blastic: radiodense, increase serum alk phosphatase

lytic: lucencies in bone on xray, tumors produce factors activating osteoclasts, hypercalcemia

21

multiple myelom

osteolytic metastases

22

prostate cancer

osteoblastic metastases

23

stomach adenocarcinoma s-->

virchows left supraclavicular node

24

breast cancer --> l

lung bone

25

colorectal cancer --->

liver

26

renal adenocarcinoma -->

lung

27

lung -->

adrenal , liver

28

melanoma -->

liver, lung

29

prostate -->

bone

30

testicular tumor -->

para aortic nodes

31

more important parameter:

stage

32

grade =

1-4 based on mitotic index or uptake of BrdU (thymidine analog uptaked during S phase)

33

well differntiated

grade 1

34

nearly anaplastic

grade 4

35

poorly differentiated

grade 3

36

moderately diff.

grade 2

37

staging TNM

t= size of tumor
N= nodal involvement
M= distant metastases

38

dukes system

staging for colorectal cancer

39

ann arbor system

staging for lymphomas

40

female cancer death

lung
breast
colorectal

41

male cancer death

lung
prostate
colorectal

42

male cancer incidence

prostate
lung
colorectal

43

female cancer incidence

breast
lung
colorectal

44

gastric cancer is more common in

Japan

45

radon

occupational lung cancer

46

vinyl chloride

occupational angiosarcoma of liver

47

nickle

occupational nose, lung

48

arsenic

occupational lung, skin, hemangiosarcoma

49

asbestos

occupational lung, mesothelioma, GI tract

50

aniline dyes

bladder cancer

51

pipe fitter, ship builders

mesothelioma from asbestos

52

most common cancer type with age

carcinoma