Neoplasia: Tumor Characteristics

Question 1

These are the changes in structural pattern of tumor cells.

Answer 1

• Increase in size
• Irregular shape
• Irregular pattern
• Anisocytosis
• Anisokaryosis
• Cell Crowding

Question 2

These are the changes in the cytoplasm in tumor cells.

Answer 2

• Acidophilia by orangeophilia
• Excessive inclusion bodies
• Abnormal vacuolation

Question 3

These are the changes in nucleus in tumor cells.

Answer 3

• Low N:C ratio
• Irregular size and shape
• Deep pigmentation (Hyperchromicity)
• Multinucleated (More mitosis)
• More nucleoli
• Increased distribution of chromatin
• Thick nuclear membrane
• Necrotic or degenerative changes

Question 4

What are the microscopic features of malignancy?

Answer 4

• Pleomorphism
• Abnormal Nuclear Morphology
• Mitosis
• Loss of Polarity
• Necrosis

Question 5

This is the variation in size and shape of a tumor.

Answer 5

Pleomosphism

Question 6

This is the normal N:C ratio compared to a malignant cell.

Answer 6

• 1:4 is normal
• 1:1 indicated malignant celll

Question 7

Why does abnormal nuclear stains more darkly than usual?

Answer 7

Hyperchromasia

Question 8

These are the features of abnromal nuclear morphology.

Answer 8

• Large nucleus
• Large nucleoli
• Nuclear pleormophism
• Hyperchromasia
• Clumped chromatin

Question 9

This refers to a higher rate of proliferation and are usually manifest in atypical and bizzare figures.

Answer 9

Mitosis and Mitotic Figures

Question 10

This referes to the dsiturbed architecture with respect the basement membrane and usually appreciated in epithelia.

Answer 10

Loss of Polarity

Question 11

This manifests due to ischemia mainly because of rapid growth of tumor that outgrows and suffocates the supply.

Answer 11

Necrosis; Necrotic Ischemia

Question 12

This is the most common type of necrosis present in cancer.

Answer 12

Coagulative Necrosis